蒙药扎冲十三味丸对大鼠急性血瘀模型血液流变学的影响

目的 观察Gi13对大鼠急性血瘀模型血液流变学的影响.方法 采用皮下注射0.1％盐酸肾上腺素复合冰水浴大鼠血瘀模型,各组大鼠用乌拉坦麻醉后腹主动脉取血,测定大鼠血液流变学各参数及血小板聚集功能等指标.结果 Gi13高、中剂量组均能显著降低急性血瘀模型大鼠低切变率(1s-1)全血黏度、中切变率(50 s-1)全血黏度、血浆纤维蛋白原浓度、红细胞压积、血沉、红细胞聚集指数、血小板聚集率等指标(P＜0.05).结论 Gi13对大鼠急性血瘀模型血液流变学及血小板功能的异常变化有明显的改善作用.

Effect of traditional mongolian medicine garidi-13 pills on hemorheology in acute blood stasis rats

Objective To observe the effect of Garidi-13 pills on hemorheology in acute blood stasis rats.Methods The acute blood stasis rat model was established with subcutaneous injection of 0.1% adrenaline hydrochloride with ice water bath in 2 h.After anesthesia with urethane,blood was taken from the abdominal artery,and then its hemorheological parameters,platelet aggregation and other indicators were measured.Results Both the high and medium dose groups of Gi13 pills significantly reduced the low(1 s-1),and medium shear rate(50 s-1) of the blood viscosity,plasma fibrinogen concentration,hematocrit,erythrocyte sedimentation rate,erythrocyte aggregation index,and platelet aggregation rate(P <0.05) in acute blood stasis rats.Conclusion Gi13 pills can significantly improve the abnormalities of platelet function and hemorheology in acute blood stasis rats.