心肌纤维化发病机制及治疗的研究进展

随着全世界人口老龄化进程不断推进,纤维化相关的心血管疾病的发病率逐年升高,受到了学者们的广泛关注。心肌纤维化(myocardial fibrosis,MF)是一种以细胞外基质(extracellular matrix,ECM)成纤维细胞过度增殖、胶原沉积及异常分布为特征的疾病,是多种心血管疾病发展至终末的共同病理表现。其发病机制多样化(如RAAS系统的激活、TGF-β等),信号转导通路复杂,并与糖尿病、甲状腺疾病等全身代谢性疾病息息相关。研究MF的发病机制有助于预防心血管疾病的发生,为治疗提供思路。然而,MF的发生机制复杂,目前尚未完全阐明。

Research progress on pathogenesis and treatment of myocardial fibrosis

With the development of the aging of the world’s population,the incidence of fibrosis-related cardiovascular diseases has increased every year,which has attracted wide attention of scholars.Myocardial fibrosis(MF)is a disease characterized by excessive proliferation,collagen deposition and abnormal distribution of fibroblasts in extracellular matrix(ECM).It is a common pathological manifestation of the development of a variety of cardiovascular diseases to the end.Its pathogenesis is diversified(such as activation of the RAAS system,TGF-β,etc.).Signal transduction pathways are complex,and are closely related to systemic metabolic diseases such as diabetes and thyroid diseases.Studying the pathogenesis of MF helps prevent the occurrence of cardiovascular diseases and provides ideas for treatment.However,the mechanism of MF is complicated and has not yet been fully elucidated.