黑色素瘤抗原-A10蛋白在肺癌中的表达及意义

目的：观察黑色素瘤抗原(MAGE)-A10在不同类型肺癌的表达分布和临床意义。方法：应用组织芯片技术、免疫组化S-P法研究MAGE-A10在65例肺癌患者的表达情况，并分析其与病理类型、病理分级的关系。结果：MAGE-A10蛋白在小细胞肺癌、肺鳞癌和肺腺癌的阳性表达率分别为36．4％、76．5％和40．0％，在大细胞肺癌和支气管肺泡癌中未见阳性表达。MAGE-A10蛋白在小细胞肺癌与非小细胞肺癌的表达率未见差异，与肺鳞癌、肺腺癌的病理分级也无明显关系。结论：MAGE-A10分子在肺鳞癌中表达率最高，肺腺癌和小细胞肺癌次之，大细胞肺癌和支气管肺泡癌中未见表达，对鉴别诊断可能有辅助意义，并可能成为某些肺癌生物学治疗的潜在靶点。

Expression of MAGE-A10 protein and its clinical significance in human lung cancer

Objective: To explore the expression and the clinical significance of MAGE-A10 in human lung cancer. Methods: By using tissue array and S-P immunohistochemical methods with anti-MAGE-A10 monoclonal antibody, the expression of MAGE-A10 protein in 65 cases lung cancer was investigated and the correlation of MAGE-A10 expression with histological types and pathological grades was also evaluated. Results: The positive expression rates of MAGE-A10 were 36.4% in small cell lung carcinoma, 76.5% in squamous cell lung carcinoma and 40.0% in lung adenocarcinoma repectively, but no positive case can be found in large cell lung carcinoma and bronchioloalveolar carcinoma. It was no statistical significance between the expression ratio of MAGE-A10 protein in the small cell lung carcinoma(SCLC) and non-small cell lung carcinoma(NSCLC). The correlation of pathological grades in both the squamous cell carcinoma groups and the adenocarcinoma groups with expression of MAGE-A10 was also not been found. Conclusion: The expression ratio of MAGE-A10 in squamous cell lung carcinoma was the highest, followed by that in lung adenocarcinoma and SCLC suggesting that MAGE-A10 might be used as an useful marker in pathological diagnosis as well as a potential target in biological therapy of lung cancer.