血脂异常与非酒精性脂肪肝发病关系前瞻性队列研究

目的 了解血脂异常与非酒精性脂肪肝(NAFLD)发病的关系,为NAFLD的预防控制提供参考依据.方法 采取前瞻性队列研究,于2014年1-12月采用方便抽样方法在天津市第一中心医院健康管理科抽取2658名非NAFLD体检者进行随访调查,分析血脂异常与NAFLD发病的关系.结果 2 658名非NAFLD体检者在4年中共发...

Association between dyslipidemia and nonalcoholic fatty liver disease incidence:a prospective cohort study

Objective To investigate the correlation between dyslipidemia and nonalcoholic fatty liver disease(NAFLD)and to provide references for the prevention and control of NAFLD.Methods Using convenient sampling,we recruited2658 physical examinees(mean age=41.98±13.99,53.3%males)without NAFLD at the First Central Hospital of Tianjin Municipality from January through December 2014.A follow-up survey was conducted among all the participants during2018 and the correlation between baseline dyslipidemia and the incidence of NAFLD was analyzed.Results By the end of follow-up in 2018,totally 875 NAFLD patients were identified among the all participants,with an incidence density of83/1000 person-years.The results of multivariate Cox proportional hazard risk(HR)regression analysis revealed that high baseline serum triglyceride(TG)(HR=1.324,95%confidence interval[95%CI]:1.083–1.617)and low-density lipoprotein cholesterol(LDL-C)(HR=1.232,95%CI:1.030–1.474)could increase the incidence of NAFLD in males and high serum TG increase the incidence of NAFLD in females after adjusting for age,body mass index(BMI),systolic blood pressure(SBP),diastolic blood pressure(DBP),alanine aminotransferase(ALT),uric acid(UA),fasting plasma glucose(FPG)and blood lipid profiles.Conclusion Dyslipidemia is associated with NAFLD incidence and the prevention of elevated serum TG and LDL-C might be one of effective measures for the prevention and control of NAFLD.