老年难治性心力衰竭患者连续性肾脏替代治疗的效果及对血清因子水平的影响

目的 探讨老年难治性心力衰竭患者连续性肾脏替代治疗(continuous renal replacement therapy,CRRT)的效果及对血清C反应蛋白(Creactive protein,CRP)、半乳糖凝集素-3 (galectin-3,Gal-3)、氨基末端脑钠肽前体(N-terminal pro-bra...

Effect of continuous renal replacement therapy on elderly patients with refractory heart failure and its effect on serum factor levels

Objective To investigate the effect of continuous renal replacement therapy(CRRT)in the treatment of elderly patients with refractory heart failure and its effect on serum levels of C reactive protein(CRP),galectin-3(Gal-3),N-terminal pro-brain natriuretic peptide(NT-proBNP),heart fatty acid binding protein(H-FABP)and Nexilin.Methods We recruited 84 elderly patients with refractory heart failure admitted to our hospital from June 2016 to February 2018,and randomly divided them into study group(n=42)and control group(n=42).While all patients received the conventional treatment,patients in study group were also treated with CRRT.Left ventricular ejection fraction(LVEF),stroke volume(SV),left ventricular end-diastolic diameter(LVEDD),maximum mitral flow velocity E-peak/A-peak(E/A),serum levels of CRP,Gal-3,NTproBNP,H-FABP and Nexilin,and clinical effects were compared before and after CRRT between the two groups.Results After the treatment,LVEF,SV and E/A became higher in study group than in control group(t=3.081,4.131 and 3.043 respectively;P=0.003,0.000 and 0.003 respectively);LVEDD and the serum levels of CPP,Gal-3,NT-proBNP,H-FABP and Nexilin were lower in study group than in control group(t=-3.520,-7.468,-6.315,-5.008,-4.133 and-5.361 respectively;P=0.001,0.001,<0.001,<0.001,<0.001 and<0.001 respectively).Clinical effects were also better in study group than in control group(Z=-2.012,P=0.044).Conclusion CRRT is better than the conventional therapy in the treatment of elderly patients with refractory heart failure.CRRT can also significantly reduce the serum levels of CRP,Gal-3,NT-proBNP,H-FABP and Nexilin.