| 运用基因调控技术探析膜联蛋白A2的病理作用 |
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| 引用本文： | 贾梦真,黄岩杰,杨晓青,韩红艳,张建江.运用基因调控技术探析膜联蛋白A2的病理作用[J].中国比较医学杂志,2021(1). |
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| 作者姓名： | 贾梦真 黄岩杰 杨晓青 韩红艳 张建江 |
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| 作者单位： | 河南中医药大学第一临床医学院;河南中医药大学第一附属医院儿科;河南中医药大学;郑州大学第一附属医院儿科 |
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| 基金项目： | 河南省自然科学基金资助项目(182300410346);河南省高校科技创新团队支持计划(18IRTSTHNO28);河南省中医药科学研究重大专项课题(2018ZYZD05)。 |
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| 摘 要： | 膜联蛋白A2(Annexin A2,ANXA2)是一种多功能的钙依赖性磷脂结合蛋白,既往报道ANXA2与多种肿瘤疾病的发生发展密切相关。近年来利用基因调控技术敲低、敲除和过表达ANXA2的实验研究发现:ANXA2功能复杂,参与了细胞增殖、肿瘤细胞侵袭、新血管生成、纤溶酶系统、炎症反应、上皮-间充质转化和抗癌药物的耐药性及副作用等病理过程,因此涉及多种肿瘤和非肿瘤疾病的发生发展。本文根据国内外最新进展在基因层面对ANXA2上述病理作用及其机制进行综述,精准揭示ANXA2能否作为相关疾病早期筛查和治疗的靶点。
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| 关 键 词： | 膜联蛋白A2 基因调控 病理作用 |
Pathological effects of annexin A2 investigated by gene regulation techniques |
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| JIA Mengzhen,HUANG Yanjie,YANG Xiaoqing,HAN Hongyan,ZHANG Jianjiang.Pathological effects of annexin A2 investigated by gene regulation techniques[J].Chinese Journal of Comparative Medicine,2021(1). |
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| Authors: | JIA Mengzhen HUANG Yanjie YANG Xiaoqing HAN Hongyan ZHANG Jianjiang |
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| Institution: | (First School of Clinical Medicine,Henan University of Traditional Chinese Medicine,Zhengzhou 450046,China;Department of Pediatrics,the First Afiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450099;Henan University of Traditional Chinese Medicine,Zhengzhou 450046;Department of Pediatrices,the First ffiliated Hospital Pediatrics of Zhengzhou University,Zhengzhou 450052) |
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| Abstract: | Annexin A2(ANXA2)is a multifunctional calcium-dependent phospholipid-binding protein.Previous reports have shown that ANXA2 is closely related to the occurrence and development of various tumors.However,knockdown,knockout or overexpression of ANXA2 using gene regulation technologies have indicated that ANXA2 is multifunction and involved in various pathological processes including cells proliferation,tumor cell invasion,neoangiogenesis,the plasmin system,inflammatory response,epithelial-mesenchymal transition,anti-cancer drug resistance,and side effects.It also participates in the occurrence and development of tumors and non-tumor diseases.These pathological effects and pathways of ANXA2 at the genetic level were summarized on the basis of recent developments and we also explored whether ANXA2 can be used as a target for early diagnosis and treatment of the related diseases. |
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| Keywords: | ANXA2 gene regulation pathological effects |
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