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| β-肾上腺素受体激酶与心力衰竭治疗的研究进展 | |
| 引用本文： | 刘欣,康毅. β-肾上腺素受体激酶与心力衰竭治疗的研究进展[J]. 中国心血管杂志, 2006, 11(5): 380-381 |
| 作者姓名： | 刘欣 康毅 |
| 作者单位： | 1. 天津医科大学,病理生理学教研室,天津,300070 2. 天津医科大学,药理学教研室,天津,300070 |
| 摘 要： | 全球大约有2 300万人患有心力衰竭,对β-肾上腺素受体的反应性降低是心力衰竭的特征并由此导致心脏功能异常。通过转基因的办法抑制β-肾上腺素能受体激酶1(βARK1)进而改善衰竭心脏的收缩功能和对β-肾上腺素能神经兴奋的反应性,使得βARK1的抑制成为重要的治疗心力衰竭的手段。本文就βARK1研究的最新进展作一综述。 |
| 关 键 词： | β-肾上腺素受体激酶 心力衰竭 治疗学 |
| 文章编号： | 1007-5410(2006)05-0380-02 |
| 收稿时间： | 2006-03-06 |
| 修稿时间： | 2006-03-21 |
Advance research of β-adrenergic receptor kinase and treatment for heart failure |
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| LIU Xin,KANG Yi. Advance research of β-adrenergic receptor kinase and treatment for heart failure[J]. Chinese Journal of Cardiovascular Medicine, 2006, 11(5): 380-381 | |
| Authors: | LIU Xin KANG Yi |
| Affiliation: | 1. Department of Pathphysio-logy ; 2. Department of Pharmacology, Tianjin Medical University, Tianjin 300070, China |
| Abstract: | Heart failure affects 23 million people worldwide and results from cardiac dysfunction characterizered by decreased responsiveness to β-adrenergic stimulation.Recently,there are some evidence to targeted β-adrenergic receptor kinase(βARK1) inhibition by gene transfer to improve contractile function and β-adrenergic responsiveness in failing human myocardium.This has great importance to future heart failure therapy because it provides evidence for the therapeutic effectiveness of βARK1 inhibition in failing human myocardium. |
| Keywords: | β-adrenergic receptor kinase Heart failure Therapy |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |