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| 喉癌声门上型微血管生成及其临床意义 | |
| 引用本文： | 杨蕾,陈文宽,曾宗渊,郭朱明. 喉癌声门上型微血管生成及其临床意义[J]. 中国耳鼻咽喉头颈外科, 2009, 16(3): 136-139 |
| 作者姓名： | 杨蕾 陈文宽 曾宗渊 郭朱明 |
| 作者单位： | 华南肿瘤学国家重点实验室,中山大学附属肿瘤防治中心头颈科,广东,广州,510060;华南肿瘤学国家重点实验室,中山大学附属肿瘤防治中心头颈科,广东,广州,510060;华南肿瘤学国家重点实验室,中山大学附属肿瘤防治中心头颈科,广东,广州,510060;华南肿瘤学国家重点实验室,中山大学附属肿瘤防治中心头颈科,广东,广州,510060 |
| 摘 要： | 目的了解喉鳞状细胞癌（简称喉癌）声门上型微血管生成与其临床病理因素的关系，评估其微血管密度（microvessel density，MVD）对判断喉癌声门上型预后的价值。方法回顾性分析我院初治确诊并行原发灶切除的51例喉癌声门上型患者临床病理资料，选取6例声门上区非肿瘤病变作为对照组。取相应石蜡切片行CD105单克隆抗体免疫组化染色，并计数CD105染色阳性的MVD，统计分析MVD与临床病理因素及预后的关系。结果对照组的MVD中位数为2。实验组51例喉癌声门上型标本MVD中位数为9，较对照组明显增高。高MVD表达与淋巴结转移及临床晚期显著相关，P值分别为0．025和0．020。总体5年生存率为54．9％，肿瘤低分化、局部晚期、淋巴结转移及临床晚期均与5年生存率下降有关，MVD则对喉癌声门上型5年生存率无影响。结论喉癌声门上型微血管生成可能与肿瘤淋巴结转移及I临床晚期相关，但尚不能说其导致患者生存率下降。 |
| 关 键 词： | 喉肿瘤 癌 鳞状细胞 微血管密度 |
| 收稿时间： | 2008-11-24 |
Clinical significance of microvessel formation in supraglottic carcinoma |
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| YANG Lei,CHEN Wenkuan,ZENG Zongyuan,GUO Zhuming. Clinical significance of microvessel formation in supraglottic carcinoma[J]. Chinese Archives of Otolaryngology-Head and Neck Surgery, 2009, 16(3): 136-139 | |
| Authors: | YANG Lei CHEN Wenkuan ZENG Zongyuan GUO Zhuming |
| Affiliation: | State Key Laboratory of Oncology Southern China;Department of Head and Neck Oncology;Cancer Center;Sun Yat-sen University;Guangzhou;Guangdong;510060;China |
| Abstract: | OBJECTIVE The study detected vascular microvessel density(MVD)in supraglottic carcinoma to investigate the correlation between MVD and clinicopathologic factors, and to assess prognosis significant in supraglottic carcinoma. METHODS Fifty-one patients of supraglottic carcinoma who underwent excision of whole or partial larynx were included in this study, and their clinical data were reviewed. Immunohistochemical analysis was performed with antibodies of CD105 to recognize vascular microvessel. Positive stai... |
| Keywords: | Laryngeal Neoplasms Carcinoma Squamous Cell microvessel density |
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