2009年我院126例药品不良反应报告分析

目的了解医院药品不良反应（ADR）的发生情况,促进临床安全、合理用药。方法应用Excel软件对收集的2009年126例ADR报告进行统计分析。结果 126例ADR涉及的药品有89种,抗感染药物居首位（54例,42.86%）;喹诺酮类是引发ADR的主要抗感染药（14例,11.11%）,其次是头孢菌素类（12例,9.52%）;给药途径以静脉滴注为主（91例,72.22%）;ADR出现在用药1h内63例（50.00%）;严重的ADR有17例,新的ADR有17例,有1例既是严重的又是新的ADR;临床表现以皮肤及其附件损害最常见（59例,44.70%）,其次为消化系统（25例,18.94%）及神经系统损害（14例,10.61%）。结论医院应重视ADR的监测和报告工作,以减少或避免ADR的发生,确保临床用药安全。

Analysis on 126 Cases of ADR Reports in Our Hospital in 2009

Objective To understand the occurrence status of adverse drug reactions（ADR） in our hospital to promote clinical safe and rational use of drugs.Methods Excel software was used to statistically analyze 126 cases of ADR reports collected in our hospital in 2009,classifying in aspects of the reporting departments,patients＇ gender and age,routes of administration,ADR emerged time and ADR-induced drugs,involving organs or systems,clinical manifestations and severe ADR and so on.Results 126 cases of ADR involved 89 kinds of drugs.Anti-infective drugs ranked first（54 cases,42.86%）;quinolones was the major anti-infective drug inducing ADR（14 cases,11.11%）,followed by cephalosporins（12 cases,9.52%）;the main route of administration was intravenous infusion（91 cases,72.22%）;ADR within 1 h after using medication was in 63 cases（50%）;serious ADR was in 17 cases and new ADR in 17 cases,1 case was serious and new ADR;the clinical manifestations with the damage of skin and its annexes（59 cases,44.70%） were most common,followed by the digestive system（25 cases,18.94%） and nervous system damage（14 cases,10.61%）.Conclusion Should pay attention to ADR monitoring and reporting in order to reduce or avoid the occurrence of ADR for ensuring the clinical safety of drug use.