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| 狂犬病北京3aG-V生产株的特性研究 | |
| 引用本文： | 史秀山. 狂犬病北京3aG-V生产株的特性研究[J]. 中华实验和临床病毒学杂志, 2004, 18(4): 348-350 |
| 作者姓名： | 史秀山 |
| 作者单位： | 570000,海口,海南省生物制品研究所科研一室 |
| 基金项目： | 国家“863”高技术发展研究计划项目([2 0 0 0 ] 14 6)，国家“九五”科技攻关计划 ([1996] 10 0 -0 3 1)，国家卫生部基金([1995 ]2 3) |
| 摘 要： | 目的 研究狂犬病北京固定毒Veto细胞适应株3aG-V生产株的生物学特性。方法 观察毒株形态、培养条件、致病性、免疫原性、毒力试验及其检查在中枢神经系统是否形成病毒包涵体(尼氏小体)。结果 狂犬病北京aG固定毒3aG-V株具有抗原性好、培养产毒量高、保持有aG固定株弱毒性、传代稳定、无变异的特性。结论 狂犬病北京aG固定毒3aG-V株可作为替代地鼠肾细胞狂犬病疫苗aG毒株，用于Veto细胞培养病毒生产出毒液毒力高、灭活后效力高、安全性好的纯化Veto细胞狂犬病疫苗的生产用疫苗株。 |
| 关 键 词： | 狂犬病疫苗 固定 地鼠肾细胞 尼氏小体 中枢神经系统 抗原性 观察 毒株 后效 产毒量 |
| 修稿时间： | 2004-09-14 |
Biological characteristics of the adapted rabies virus 3aG-V in Vero cell |
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| SHI Xiu-shan. Laboratory of Research,Hainan Province Institute of Biological Products,Haikou ,China. Biological characteristics of the adapted rabies virus 3aG-V in Vero cell[J]. Chinese journal of experimental and clinical virology, 2004, 18(4): 348-350 | |
| Authors: | SHI Xiu-shan. Laboratory of Research Hainan Province Institute of Biological Products Haikou China |
| Affiliation: | Laboratory of Research, Hainan Province Institute of Biological Products, Haikou 570000, China. |
| Abstract: | Objective To study the biological features of the adapted rabies virus 3aG-V in Vero cell. Methods The virus structure, culture condition, pathogenicity, immunocompetence, toxicity and protective efficiency were studied. Results The rabies virus 3aG-V strain could well adapt to Vero cell, the pathogenicity was very weak and the immunogenicity was very good. Conclusion The Vero cell-adapted rabies virus strain may possibly be used as a vaccine strain. |
| Keywords: | Rabies vaccines Vero cells Biological phenomena Toxicity tests Robies/virus Immunocompetence |
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