生长抑素受体和雌激素受体在原发性乳腺癌中的表达及其意义

目的研究生长抑素受体(SSTR)与雌激素受体(ER)、孕激素受体(PR)在原发性乳腺癌中的表达及其意义。方法 采用免疫组织化学链霉菌抗生物素蛋白-过氧化酶(SP)法检测SSTR和ER、PR在68例乳腺癌中的表达。结果 在68例乳腺癌中,SSTR阳性表达44例(64.70％),ER、PR阳性表达51例(75.70％),ER、PR和SSTR同时阳性表达阳性41例(60.29％)。ER、PR和SSTR两者表达呈正相关(r=0.651 6,P<0.05)。SSTR阳性患者复发率和死亡率低于SSTR阴性者(P<0.05);SSTR阳性且ER、PR阳性患者复发率和死亡率明显低于SSTR阴性ER、PR阴性患者(P<0.01)。病理分化低的有47例,SSTR阳性表达36例(P>0.05)。结论SSTR表达与ER、PR表达有明显相关性,有可能作为判断乳腺癌预后的指标。

Relationship between expression of somatostatin receptor and estrogen receptor and the prognosis of primary breast cancer

Objective To study the relationship between the expression of somatostatin receptor (SSTR) and estrogen receptor (ER) and the prognosis of breast cancer. Methods Immunohistochemical method was used to detect the expression of SSTR and ER in 68 patients with breast cancer. Results The positive rate of expression of ER and/or PR and SSTR was 75. 00% (51/68) and 64. 00% (44/ 68), respectively. The positive rate of co-expression of ER and/or PR and SSTR was 60.29 % (41/68) . SSTR expression was correlated significantly with ER and/or PR expression (r=0.651 6, P <0.05). There was significant difference in the recurrence rate and mortality between the patients positive for SSTR and those negative for SSTR ( P <0.05). The recurrence rate and mortality of the patients positive for both SSTR and positive ER, PR was lower significantly than that of the patients negative for both SSTR and ER, PR ( P < 0.01). Of the 47 cases having lower tumor grandes, 36 were postive for SSTR expression ( P >0.05). Conclusion There is a good correlation between SSTR and ER, PR, and SSTR may possibly be of value in the prediction of the prognosis of breast cancer.