血管内皮生长因子在胃腺癌中的表达及意义

目的　探讨血管内皮生长因子 (VEGF)在判断胃腺癌转移和预后中的作用。方法　应用免疫组织化学S P法检测 76例胃腺癌组织和 10例正常胃组织中VEGF的表达水平 ,比较VEGF的不同表达率与生存率的关系及其与肿瘤特征的相关性。结果　胃腺癌组织中VEGF阳性表达率为 72 .4 % ,较正常组织显著增高 (P <0 .0 5 ) ,与Borrmann分型、浸润深度、肿块大小、淋巴结转移程度比较相关显著 (P <0 .0 5 ) ,与分化程度相关不显著 (P >0 .0 5 ) ,VEGF阳性表达者的生存时间较阴性者短 (P <0 .0 5 )。结论　VEGF与血管发生密切相关 ,可作为判断胃腺癌转移和预后的重要指标。

Expression and significance of vascular endothelial growth factor in gastric adenocarcinoma

Objective To determine the action of vascular endo thelial growth factor(VEGF) in metastasis,prognosis of gastric adenocarcinoma. Methods To test the expression of VEGF and to compare the relationship between the expression rate of VEGF and the survival rate, 76 cases of paraffin-embedded specimens of gastric adenocarcinoma tissues were observed by using the S-P immunohistochemistry,and 10 cases of normal gastric mucosa tissue specimens were selected as a control group. Results The expression of VEGF in gastric adenocarcinoma was 72.4%, obviously higher than that in normal gastric mucosa tissues(P< 0.05). Expression of VEGF related to Borrmann stage,the depth of invasion,neoplasm diametre,lymphatic node metastasis(P< 0.05),but did not relate to differentiation degree(P>0.05).With the increasing of positive expressions of VEGF,the survival time became shorter(P< 0.05). Conclusion VEGF expression is highly related to angiogenesis,might act as an important index for judging the metastasis and prognosis in gastric adenocarcinoma.