葛根素注射液联合西药常规治疗心力衰竭疗效的Meta分析

目的:系统评价葛根素注射液联合西药常规治疗心力衰竭的临床疗效。方法:计算机检索Pub Med,CENTRAL,中国期刊全文数据库(CNKI),维普数据库(VIP),EMbase,中国生物医学文摘数据库(CBM)和万方(Wanfang)等数据库,纳入随机对照试验,经过文献筛选和评价质量后提取有效数据进行Meta分析。结果:共纳入16个RCTs合计1 291例患者。Meta分析结果显示,葛根素注射液联合西药常规治疗心力衰竭在提高临床综合疗效OR=3.95,95%CI(2.84,5.49)],左室射血分数MD=8.43,95%CI(3.41,13.45)],每搏搏出量MD=4.98,95%CI(3.20,6.75)],心输出量MD=0.57,95%CI(0.19,0.94)],心脏指数MD=0.77,95%CI(0.33,1.20)]和降低心率MD=9.71,95%CI(6.52,12.89)]等指标上均优于单用西药治疗,其差异均具有统计学意义(P0.05)。结论:葛根素注射液联合西药常规治疗心力衰竭的临床疗效优于单用西药。

Clinical Efficacy on Gegensu Injection Combined with Western Medicine for Curing Heart Failure

Objective: To systematically review the efficacy of Gegensu injection combined with western medicine for curing Heart failure. Method: Such databases as PubMed, CENTRAL, CNKI, VIP, EMbase, Wanfang and CBM were electronically searched to collect the randomized controlled trials. The document screening and quality evaluation were conducted to extractvalid data for a Meta-analysis. Result: Totally 16 RCTs involving 1 291 cases were included. The results of Meta-analysis showed that compared with the pure western medicine treatment, the combination of Gegensu injection and western medicine were superior in clinical comprehensive effect OR=3.95, 95%CI(2.84,5.49)], left ventricular ejection fraction MD=8.43, 95%CI(3.41,13.45)], stroke volume MD=4.98, 95%CI(3.20,6.75)], cardiac output MD=0.57, 95%CI(0.19,0.94)], cardiac index MD=0.77, 95%CI(0.33,1.20)] and reduction of heart rate MD=9.71, 95%CI(6.52,12.89)], with significant statistical differences (P<0.05). Conclusion: Compared with the pure western medicine treatment, the combination of Gegensu injection and western medicine has a higher clinical efficacy in the treatment of heart failure.