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Fine Structure of Leukocytes in Infectious Mononucleosis: In Vivo and In Vitro Studies

Authors:	DOUGLAS, STEVEN D. FUDENBERG, H. HUGH GLADE, PHILIP R. CHESSIN, LAWRENCE N. MOSES, HAROLD L.

Affiliation:	¹ Laboratory of Experimental Pathology NIAMD, Laboratory of Clinical Investigation, NIAID, National Institutes of Health, Bethesda, Maryland and Department ofMedicine, University of California Medical Center, San Francisco, California.

Abstract:	The peripheral blood mononuclear cell population in patients with heterophile positive infectious mononucleosis is comprised of small and mediumsized lymphocytes, monocytes, increased numbers of lymphoid-plasma (LP)cells, and large lymphocytoid cells with abundant polysomes. Cell-lines derived from these patients contain a spectrum of cells of the lymphoid plasmacell series. These cultures are morphologically indistinguishable from Burkittlymphoma and leukemic suspension cultures. A large portion of the cellspresent in these continuous suspension cultures have fine structural featuressimilar to phytomitogen stimulated lymphocytes, and to cells implicated inthe immune response. Submitted on November 26, 1968 Accepted on February 26, 1969

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