大剂量单味生大黄治疗急性黄疸型肝炎的初步观察

用大剂量单味生大黄治疗急性黄疸型肝炎80例,在改善症状、恢复肝功能等方面取得较好疗效,平均用药16天,有效率为95%,显效率为81.25%。本药使用简便,疗程短、疗效高,无严重副作用。

A Preliminary Analysis of the Effects of Single Rheum Officinale with Heavy Doses in the Treatment of Acute Icteric Hepatitis

This paper reports effective usage of single Rheum officinale(Rheum)with heavy doses in 80 cases of acute icteric hepatitis in the improvement of symptoms and liver function.The effective rate is 95%,and marked effective rate 81.25%.The daily dose of Rheum is 50g for adults,and 25-30g for children.The herb was dissoIved in water and boiled orally qd.The appetite of the patients was improved in 2-3 days after heavy dose treatment.The normal icteric index and transaminase were restored in 12.7 days and 16.4 days respectively.On average,the patients spent 19.7 days in the hospital.Generally,the patients could receive the treatment without dehydration and disturbance of electrolyte,except nausea and vomiting occurred in a few cases. Pharmacological effects and the mechanism of Rheum in the treatment of acute icteric hepatitis were also studied.It is emphatically indicated that Rheum has manifested two entirely opposite effects,depending upon different parts of the smooth muscles of intestine.For instance,it has inhibitory effect on the small intestine,whereas it has stimulating effect on the colon.This helps explain why Rheum removes pathogenic factors without damaging normal functioning of the human body. Since Rheum is a good purgative drugs,and has the function of preventing further loss of fluid as well as removing blood stasis to promote regeneration,it can be one of the medicines to deal with severe cases of hepatitis.