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| 穿心莲有效部位Poloxamer188聚合物胶束的制备工艺 | |
| 引用本文： | 刘蕾,王钰涵,韩光,张瑜. 穿心莲有效部位Poloxamer188聚合物胶束的制备工艺[J]. 河南大学学报(医学版), 2012, 0(2): 91-94 |
| 作者姓名： | 刘蕾 王钰涵 韩光 张瑜 |
| 作者单位： | 河南大学药物研究所 |
| 基金项目： | 河南大学科研基金项目(2009ZZZD006) |
| 摘 要： | 目的制备Poloxamer188穿心莲有效部位的聚合物胶束。方法薄膜水化法制备穿心莲有效部位聚合物胶束,正交设计优化处方工艺。HPLC法测定其载药量和包封率,激光粒度仪测定粒径。结果载药胶束包封率为(85.7+2.1)%,载药量为(1.11+0.09)%,粒径为(198.32+3.35)nm。结论载药Poloxamer188胶束制备工艺简便易行,为中药制剂提供了新剂型。 |
| 关 键 词： | 穿心莲有效部位 Poloxamer188 聚合物胶束 |
Preparation and formulation of poloxamer188 loaded effective parts of andrographis paniculata nees polymeric micelles |
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| LIU Lei,WANG Yu-han,HAN Guang,ZHANG Yu. Preparation and formulation of poloxamer188 loaded effective parts of andrographis paniculata nees polymeric micelles[J]. Journal of Henan University, 2012, 0(2): 91-94 | |
| Authors: | LIU Lei WANG Yu-han HAN Guang ZHANG Yu |
| Affiliation: | (Institute of Pharmaceutics of Henan University,Kaifeng,Henan 475004,China) |
| Abstract: | Objective To prepare the capsule of poloxamer188 polymeric micelles system loaded with effective parts of andrographis paniculata nees(AEP).Methods AEP loaded Poloxamer188 micelles were prepared by thin-film hydration method.The main factors affecting the drug-loading encapsulation ratio was studied by single factor analysis and optimization preparation condition was gained by orthogonal design.The drug-loading coefficient and encapsulation efficiency of AEP in micelles were determined by HPLC.The mean particle size was determined by ZetasizerH-3000 Laser Particle Size Analyzer.Results The encapsulation efficiency and drug-loading coefficient were(85.7+2.1)% and(1.11+0.09) %,respectively.The diameter was(198.32+3.35) nm.Conclusion The process is practical and simple for the preparation of AEP loaded Poloxamer188 micelles.It is a new method for the preparation of Chinese Traditional Medicine. |
| Keywords: | Effective parts of Andrographis paniculata Nees(AEP) Poloxamer188 Polymeric micelles |
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