In vivo antiplasmodial potential of three herbal methanolic extracts in mice infected with Plasmodium berghei NK65 |
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| Authors: | Pachiyappan Rajiv Gandhi Chinnaperumal Kamaraj ? Elangovan Vimalkumara and Selvaraj Mohana Roopan ? |
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| Institution: | 1. Division of Nanobiotechnology, Department of Zoology, Auxilium College (Autonomous) Affiliated to Thiruvalluvar University, Tamil Nadu 632006, India;2. Department of Biotechnology, Periyar University, Tamil Nadu 636011, India;2. Dingxi Campus of Gansu University of Chinese Medicine, Dingxi Teachers College, Dingxi 743000, China;3. Key Laboratory of Chemistry and Quality for TCM of the College of Gansu Province, Lanzhou 730000, China;4. Gansu Province Engineering Laboratory for TCM Standardization Technology and Popularization, Lanzhou 730000, China;5. Gansu Province People''s Hospital, Lanzhou 730000, China;6. Key Laboratory of Dunhuang Medicine, Ministry of Education, Lanzhou 730000, China;1. Institute of Medicinal Plant Development, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100193, China;2. Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China;3. Post-doctoral Scientific Research Center, China Academy of Chinese Medical Sciences, Beijing 100700, China;4. Stem Cell Translational Research Center, Tongji Hospital, School of Medicine, Shanghai 200065, China;5. Department of Urology, Tongji Hospital, School of Medicine, Shanghai 200065, China;6. School of Medicine and school of Bioscience, Neuroscience and Mental Health Research Institute, Cardiff University, Cardiff CF24 4HQ, UK;1. Department of Traditional Chinese and Western Medicine, Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Yangzhou University, Yangzhou 225001, China;2. Department of Neurology, Affiliated Hospital, Yangzhou University, Yangzhou 225001, China;3. Jiangsu Key Laboratory of Zoonosis, Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses, Yangzhou University, Yangzhou 225009, China;4. Medical Center, Yangzhou University, Yangzhou 225001, China;1. Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad 44000, Pakistan;2. Department of Bioinformatics and Biosciences, Faculty of Health and Life Sciences, Capital University of Science and Technology (CUST), Islamabad 44000, Pakistan;3. Department of Biochemistry and Molecular Biology, University of Gujarat, Gujrat 50700, Pakistan;1. Jiangsu Key Laboratory of Drug Screening, China Pharmaceutical University, Nanjing 210009, China;2. Jiangsu Center for Pharmacodynamics Research and Evaluation, China Pharmaceutical University, Nanjing 210009, China |
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| Abstract: | ObjectiveThe present study deals with the investigation of antiplasmodial potential of leaf methanolic extract of Aegle marmelos, Aristolochia indica and Cassia auriculata against Plasmodium berghei (NK65) infected mice.MethodsThe chloroquine-sensitive parasites P. berghei (1 × 106) were inoculated into Swiss albino mice intraperitoneally. The methanol extracts of three herbal plants were orally administered in P. berghei infected mice which were further assessed using the four-day suppressive test at different doses of 150, 300 and 600 mg/kg per day. Chloroquine (CQ) was used as the standard drug with of 1.25, 2.5 and 5 mg/kg concentrations and was orally administered.ResultsThe leaves of A. marmelos, A. indica, and C. auriculata were found to suppress P. berghei parasitaemia in Swiss albino mice by (67.0 ± 4.02)%, (72.0 ± 8.44)% and (52.7 ± 2.06)% at 600 mg/kg/d with ED50 values of 284.73, 233.77 and 562.48 mg/kg, respectively. These herbal plants increased the mean survival time of infected mice and prevented body weight loss. GC-MS analysis revealed the presence of hentriacontan-16-one (C31H62O) in A. indica extract. The histopathology study showed non-toxic to kidney and liver at 600 mg/kg/body weight.ConclusionsOverall results revealed that herbal plants may be active in the development of novel and cheap antimalarial compounds. |
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| Keywords: | Aegle marmelos L Aristolochia indica L Cassia auriculata L GC-MS histopathology in vivo antiplasmodial potential Plasmodium berghei (NK65) Swiss albino mice |
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