CHOPE方案治疗侵袭性非霍奇金淋巴瘤(NHL)40例

目的：观察CHOPE方案治疗侵袭性NHL的近期疗效。方法：80例侵袭性NHL患者，分成对照组与治疗组，每组各40例，对照组为CHOP方案：CTX 750mg／m^2静脉注射，d1；VCR1．4mg／m^2，静脉注射，d1；ADM 40mg／m^2，静脉注射，d1；强的松100mg／d，d1～5。治疗组为CHOPE方案：CHOP（同对照组）＋VP-16 100mg／d，静脉滴注，d1～3 21天为1个周期，完成2个周期以上者做疗效评价。结果：治疗组40例患者中，CR21例，PR12例．NC4例．PD3例，总有效率（CR＋PR）为82．5％。结论：CHOPE方案治疗侵袭性NHL的近期疗效满意，不良反应可耐受。

Preliminary Study of CHOPE Treatment for Patients with Advanced Non-Hodgkin's Lymphoma (NHL)

Objective: To evaluate the short-term efficacy of the CHOPE regimen for treatment of advanced NHL. Methods: Eighty cases with advanced NHL were divided evenly into 2 groups. The 40 cases in the control group were treated with the CHOP regimen, i.e. CTX 750mg/m~2 ivgtt, dl; VCR1.4 mg/m~2 iv, d1; ADM40mg/m~2 iv, d1 and Prednisone 100mg/d, d1-5. The 40 cases in the treatment group were treated with the CHOPE regimen, i.e. CHOP VP-16 100mg/d ivgtt, dl-3. The duration of one cycle was 21 days. The assessment for clinical effect was conducted for those with completion of 2 cycles of chemotherapy. Results: In the treatment group, there was a complete response in 21 cases, partial response in 12 cases, and no change in 4 cases. Progression of disease occurred in 3 cases, and the overall response rate was 82.5%. Conclusions: The CHOPE regimen can achieve a satisfactory result in the treatment of advanced NHL, and the toxicity was endurable.