| 高嘌呤饮食联合尿酸酶抑制制备大鼠高尿酸血症肾损害模型 |
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| 引用本文： | 于雪峰,李登宇,潘志华,张丽丽,李洪涛.高嘌呤饮食联合尿酸酶抑制制备大鼠高尿酸血症肾损害模型[J].中华中医药学刊,2010(8). |
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| 作者姓名： | 于雪峰 李登宇 潘志华 张丽丽 李洪涛 |
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| 作者单位： | 南昌大学附属第四医院;黑龙江中医药大学;大庆市龙南医院;黑龙江中医药大学附属第一医院; |
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| 基金项目： | 国家自然科学基金资助项目(30271629) |
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| 摘 要： | 目的:建立大鼠高尿酸血症肾损害动物模型。方法:采用不同配比的腺嘌呤和氧嗪酸钾给实验大鼠灌胃,观测实验前后大鼠血清尿酸、肌酐、尿素氮水平变化,行肾组织病理与超微病理观察。结果:各组大鼠血尿酸均有不同程度的升高,高剂量组肾损害较重,低剂量组肾损害不明显。结论:中剂量组作为高尿酸血症动物模型较为合适。
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| 关 键 词： | 大鼠 高尿酸血症 氧嗪酸钾 |
Purine Diet Urico-Oxidase Inhibitor Modeling Hyperuricemia with Kidney Lesion in Rat |
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| YU Xue-feng,LI Deng-yu,PAN Zhi-hua,ZHANG Li-li,LI Hong-tao.Purine Diet Urico-Oxidase Inhibitor Modeling Hyperuricemia with Kidney Lesion in Rat[J].Chinese Archives of Traditional Chinese Medicine,2010(8). |
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| Authors: | YU Xue-feng LI Deng-yu PAN Zhi-hua ZHANG Li-li LI Hong-tao |
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| Institution: | YU Xue-feng1,LI Deng-yu2,PAN Zhi-hua3,ZHANG Li-li2,LI Hong-tao4 (1. Fourth Affiliated Hospital of Nanchang Univercity,Nanchang 330003,Jiangxi,China,2. Heilongjiang University of Chinese Medicine,Harbin 150040,Heilongjiang,3.Daqing Longnan Hospital,Daqing 163453,4. The first The Affiliated Hospital of Heilongjiang University of Chinese Medicine,China) |
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| Abstract: | Objective:establish animal model of hyperuricemia with nephric lesion using mice.Methods:using Adenine and oxonic acid intragastric administration to mice,investigate the alteration of rat's serum,including uric acid,creatinine and urea nitrogen about.Results:blood uric acid upgraded in every group,nephric lesion in group of high dosage is serious,in low dose group it has no damage.Conclusion:Middle dosage group is suitable for the animal model of hyperuricemia. |
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| Keywords: | rat hyperuricemia oxonic acid |
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