| 正常人颈段脊柱结构内CGRP和SP阳性神经纤维的分布 |
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| 引用本文： | 刘延辉,王晖,李云峰,何建新,王劼.正常人颈段脊柱结构内CGRP和SP阳性神经纤维的分布[J].颈腰痛杂志,2006,27(5):353-355. |
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| 作者姓名： | 刘延辉 王晖 李云峰 何建新 王劼 |
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| 作者单位： | 1. 江苏省常州市武进中医院骨科,常州,213161
2. 复旦大学上海医学院解剖与组织胚胎学系,上海,200032 |
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| 摘 要： | 目的 为深入探讨颈肩痛的发病机理。方法 用免疫组织化学方法观察人颈段脊柱结构内CGRP和SP阳性神经末梢存在的情况。结果 人颈段脊柱结构的纤维层内均有CGRP和SP免疫反应阳性神经末梢存在，多数神经末梢独立行走，呈树枝状或念珠状，少量神经末梢交织网状。结论 CGRP和SP可能参与了人颈段脊柱结构的伤害性感觉信息的传递。当人颈段脊柱结构的神经末梢受刺激时，可能引起CGRP和SP的释放和传递，这可能是引起原发性颈肩痛的原因之一。
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| 关 键 词： | 颈肩痛 降钙素基因相肽(CGRP) 痛物质(SP) 脊柱 人 |
| 文章编号： | 1005-7234（2006）05-0353-03 |
| 收稿时间： | 2006-12-19 |
The distribution of CGRP and SP-positive nerve endings in normal cervical spine structures |
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| LIU Yan-hui,WANG Hui,LI Yun-feng,et al.The distribution of CGRP and SP-positive nerve endings in normal cervical spine structures[J].The Journal of Cervicodynia and Lumbodynia,2006,27(5):353-355. |
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| Authors: | LIU Yan-hui WANG Hui LI Yun-feng |
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| Institution: | 1.Department of Othopedics,The Chinese Traditional Medical Hospital of Wujin,Changzhou,Jiangsu Province,213161;2.Department of Anatomy and Histology and Embryology,Shanghai Medical College of Fudan University,Shanghai,200032 |
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| Abstract: | Objective In order to understand the pathogenesis of neck and shoulder pain.Methods: Multi-structures of human cervical spinal column were immunostained with anti-CGRP and anti-SP antibody.Results There were CGRP and SP-positive nerve endings in many kinds of fibrous coats of human cervical spinal column.Most of them present arborization or beads,few of them present reticule.Conclusion The present results suggest CGRP and SP may participate in transmission of nociceptive message among human cervical spinal column.When the nerve endings of human cervical spinal column were stimulated,CGRP and SP may be released and transmitted by the nerve endings.They may be one of the causes which arouse primary neck and shoulder pain. |
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| Keywords: | neck and shoulder pain calcitonin gene related peptide(CGRP) substance pain(SP) human being |
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