Determination of gastric-emptying profiles in the rat: influence of oil structure and volume |
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| Authors: | K.J. Palin D.R. Whalley C.G. Wilson S.S. Davis A.J. Phillips |
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| Affiliation: | 1. Department of Physiology and Pharmacology, Medical School and Department of Pharmacy, University of Nottingham, NG7 2RD U.K.;1. Merck, Sharp and Dohme Research Laboratories, Hoddesdon, Herts, EN11 9BU U.K. |
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| Abstract: | ![]()
A simple non-invasive technique was developed for the determination of the gastric-emptying rate of oils in rats, employing a gamma camera and 99mTc-sulphur colloid as the oil phase marker. Using this method the gastric emptying of 3 oils, arachis oil, Miglyol 812 and liquid paraffin, was investigated. It was shown that both the oil volume and chemical structure altered the rate of gastric emptying. |
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| Keywords: | Correspondence address: Department of Physiology and Pharmacology Medical School Queen's Medical Centre University of Nottingham Nottingham NG7 2UH U.K.. |
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