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Tissue microarrays, or the advent of chips in pathology
Authors:Terris Benoît  Bralet Marie-Pierre
Affiliation:Services d'Anatomie et de Cytologie Pathologiques, AP-HP, H?pital Cochin, 27, rue du Faubourg- Saint-Jacques, 75614 Paris Cedex, France. benoitterris@hotmail.com
Abstract:Tissue microarray technology is a new method used to analyze several hundred tumor samples on a single slide allowing high throughput analysis of genes and proteins on a large cohort. The method consists to core tissues from paraffin-embedded tissue donor blocks and placing them into a single paraffin block. Despite the low amount of tissue analyzed by tissue microarray, different studies have demonstrated a high concordance of protein expression between this technique and the conventional tissue sections.
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