119例阑尾炎手术患者抗菌药物预防应用调查分析

目的分析阑尾炎手术患者抗菌药物应用情况,并进行评价。方法抽取某院普通外科2006年全年阑尾炎住院手术患者病历119份,统计其抗菌药物应用情况。结果119例阑尾炎手术患者抗菌药物使用率为100%,使用最多的抗菌药物为头孢菌素类,例次使用率为41.50%;硝咪唑类抗菌药物使用率为37.82%。Ⅱ、Ⅲ类切口手术部位感染率分别为1.92%、6.67%,两者比较,差异有显著性（χ2=8.16,P〈0.05）。Ⅱ类切口使用1种或2种抗菌药物者手术部位感染率为1.27%,使用≥3种抗菌药物者手术部位感染率为4.00%,两者差异无显著性（χ2=0.54,P〉0.05）。术后使用抗菌药物时间偏长者占87.39%,给药频率不当者占63.03%,无联合用药指征给药者占26.89%。结论目前外科抗菌药物的使用还存在较多问题,需要加强管理。

Investigation and analysis on the prophylactic application of antimicrobial agents in 119 patients with appendicitis operation

Objective To evaluate and analyse the application of antimicrobial agents in patients with appendicitis operation. Methods One hundred and nineteen medical records of patients with appendicitis operation in a general surgical department in a hospital in 2006 were chosen, the application of antimicrobial agents was analysed statistically. Results The usage rate of antimierobial agents of 119 patients was 100%, the most commonly used antimierobial agents was eephalosporins, the usage frequency was 41. 50%; the usage frequency of nitiomidazoles was 37.82%, the surgical wound infection（SWI） rate of class Ⅱ and Ⅲ incision was 1.92% and 6. 67% respectively, there was significant difference between the two （X^2 = 8.16, P〈0.0%）. SWI rate of classⅡ incision was 1.27% in patients receiving 1 or 2 antimierobial agents, and SWI rate of class Ⅱ incision was 4. 00% in patients receiving at least 3 kinds of antimierobial agents, there was no significant difference between the two （x^2 = 0. 54, P〉0.05）. 87.39%, 63.03% and 26.89% patients received long duration, inappropriate and non-indication application of antimicrobial agents respectively. Conclusion There are many problems in the application of antimierobial agents, the management of antimierobial agents should be strengthened.