非典型抗精神病药物所致恶性综合征的临床特征

本文目的是探讨非典型抗精神病药物所致恶性综合征(NMS)的临床特征,为临床早期诊断和治疗提供参考。抗精神病药物所致NMS是一种严重的药物不良反应,几乎所有的抗精神病药物均可引起。与典型抗精神病药物相比,非典型抗精神病药物所致NMS发生率更低、病情更轻、死亡率更低。不同种类非典型抗精神病药物所致NMS临床特点各异。对于老年人及应用抗抑郁药物者发生的NMS尤应引起重视,因为这些因素可增加死亡的风险。

Clinical features of Neuroleptic Malignant Syndrome caused by atypical antipsychotics

The purpose of this paper was to discuss the clinical features of Neuroleptic Malignant Syndrome( NMS) caused by atypical antipsychotics, and to provide references for early clinical diagnosis and treatment. NMS is a kind of severe adverse drug reactions and it is usually caused by antipsychotics use. Almost all kinds of antipsychotics could cause NMS. Compared with NMS caused by typical antipsychotics, NMS caused by atypical antipsychotics shows lower incidence, lower clinical severity and lower mortality rate. The clinical presentation of NMS induced by different kinds of atypical antipsychotics seems different. Particular attention should be paid to NMS elderly patients and NMS patients who are receiving antidepressant drugs as these factors might increase the risk of death.