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The C825T Polymorphism in the G-protein Beta 3 Subunit Gene in Chinese Patients with Preeclampsia
Authors:Guolin He  Xinghui Liu  Ping Fan  Rui Liu  Yi Huang  Xiaosu Wang
Affiliation:1. Department of Obstetrics and Gynecology, West China Second Hospital, Sichuan University, Chengdu, Sichuan, PR China;2. Unit of Laboratory Medicine, West China Second Hospital, Sichuan University, Chengdu, Sichuan, PR China;3. Division of Peptides Related with Human Disease, West China Hospital, Sichuan University, Chengdu, Sichuan, PR China
Abstract:
Objectives:?The objective of the study was to investigate the relationship of a C825T polymorphism of the gene encoding the G protein β3 subunit with preeclampsia in a South-West Chinese population.?Results:?In the case-control study which included 221 preeclamptic case subjects and 277 normal control subjects the allele frequency of 825C→T in the GNB3 gene was 47.29% in patients with preeclampsia and 49.28% in the control group. Furthermore, there was no significant association between the polymorphism and blood pressure levels in the case or control group. However, it showed that the TT homozygotes (n = 39) in obese patients had higher diastolic blood pressure levels than CC homozygotes (n = 47) or CT heterozygotes (n = 84) during pregnancy (p < 0.05).?Conclusion:?Our work does not provide evidence in favor of GNB3 C825T being a candidate gene for conferring genetic susceptibility to preeclampsia in a South West Chinese population.
Keywords:Pregnancy induced hypertension  Preeclampsia  G-protein beta 3 subunit gene   Polymorphism
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