Ex Vivo Programming of Antigen-Presenting B Lymphocytes: Considerations on DNA Uptake and Cell Activation |
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| Authors: | Matthew Wheeler Xotchil Cortez-Gonzalez Raffaele Frazzi |
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| Affiliation: | The Department of Medicine and Cancer Center and Biomedical Science Program, University of California, San Diego, La Jolla, California, USA |
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| Abstract: | Plasmids used in DNA vaccination not only serve as a source of antigen, but also have an important adjuvant effect. This review focuses on recent advancements made in understanding how cells internalize DNA, and how internalized DNA activates immune response pathways. We also comment on the role of B cells in both of these processes. |
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| Keywords: | activation pathways Antigen presenting cell B-cell DNA transgenesis |
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