成人肥厚型鲜红斑痣82例肥厚相关因素分析

目的 分析肥厚型鲜红斑痣患者的临床特点及导致皮损肥厚的相关因素。 方法 2010年1月至2014年8月，安徽省立医院和安徽医科大学第一附属医院皮肤科门诊成人鲜红斑痣患者纳入研究。分析肥厚型鲜红斑痣患者临床特点，并采用单因素和多因素非条件Logistic回归分析导致皮损肥厚的相关因素。结果 共收集资料完整的成年鲜红斑痣患者262例，其中肥厚型鲜红斑痣82例，男30例，女52例，年龄18 ~ 54岁，中位年龄32.5岁；66例（80.48%）表现为斑块样肥厚型，9例（10.98%）为丘疹/结节型，7例（8.54%）为混合型。肥厚型鲜红斑痣患者年龄 ≥ 30岁者占56.10%（46/82），皮损面积以11 ~ 30 cm2为主（41.46%，34/82），皮损颜色以紫红色为主（85.36%，70/82），与扁平型鲜红斑痣相比，两组差异有统计学意义（χ2 = 25.559、10.580、90.630，P < 0.05），而性别、Fitzpatrick皮肤分型、皮损部位及皮损分布与肥厚无关。多因素非条件Logistic回归分析显示，年龄≥ 30岁（OR = 2.889，95% CI：1.459 ~ 5.721）、皮损呈紫红色（OR = 19.984，95% CI：5.704 ~ 70.023）是鲜红斑痣肥厚的相关因素。 结论 年龄≥ 30岁和皮损颜色呈紫红色是肥厚型鲜红斑痣患者肥厚的相关因素。

Analysis of hypertrophy-related factors in 82 adult patients with hypertrophic port-wine stains

Wang Juan*, Wang Zhongying, Yao Xiuhua, Zhang Lanfang, Hu Bai, Zhang Siping. *Department of Dermatology, Anhui Provincial Hospital Affiliated to Anhui Medical University, Hefei 230001, China Corresponding author: Zhang Siping, Email: zh_siping@126.com 【Abstract】 Objective To analyze clinical features of and hypertrophy-related factors in patients with hypertrophic port-wine stains （PWS）. Methods Patients with PWS were enrolled into this study from Anhui Provincial Hospital and the First Affiliated Hospital of Anhui Medical University between January 2010 and August 2014. Clinical features of hypertrophic PWS were investigated. The factors related to hypertrophy in PWS were analyzed by univariate and multivariate unconditional logistic regression analyses. Results A total of 262 patients with PWS were enrolled, 82 （30 males and 52 females） of whom had hypertrophic PWS with a median age of 32.5 years （range, 18 － 54 years）. Among the 82 patients, 66 （80.48%） had plaque-like hypertrophic PWS, 9 （10.98%） had papular or nodular type, and 7 （8.54%） had mixed type; 56.10% （46/82） were aged ≥ 30 years, 41.46% （34/82） varied from 11 to 30 cm2 in lesional area, and 85.36% （70/82） showed purple lesions. There was a significant difference between patients with hypertrophic PWS and those with flat PWS in the distribution of age, lesional area and color （χ2 = 25.559, 10.580, 90.630, respectively, all P < 0.05）, while gender, Fitzpatrick′s skin type, lesional site and distribution were unrelated to hypertrophy in PWS （all P > 0.05）. Multivariate unconditional logistic regression analysis revealed that an age ≥ 30 years （OR = 2.889, 95% CI: 1.459 － 5.721） and purple lesions （OR = 19.984, 95% CI: 5.704 － 70.023） were factors related to skin hypertrophy in PWS. Conclusion An age ≥ 30 years and purple lesions seem to be hypertrophy-related factors in PWS.