非小细胞肺癌组织中FHIT和HER2的表达及其临床意义的研究

目的:探讨FHIT和HER2在非小细胞肺癌(non-small cell lung cancer,NSCLC)组织中的表达,及两者的联合表达对判断NSCLC预后和转归的价值。方法:SP法检测90例NSCLC标本中FHIT和HER2的表达。结果:NSCLC组织中FHIT蛋白失表达率53.75%(43/80)显著低于肺良性病变组织的10%(1/10),其失表达率与吸烟(P=0.000)、组织学类型(P=0.004)、淋巴结转移(P=0.002)、pTNM分期(P=0.028)及3年无瘤生存率(P=0.047)存在相关性。HER2蛋白的过表达率62.50%(50/80)却显著高于肺良性病变组织的0(0/10),其过表达率则与淋巴结转移与否(P=0.030)、pTNM分期(P=0.018)及3年无瘤生存率(P=0.028)存在相关性。FHIT蛋白的失表达与HER2蛋白过度表达呈显著负相关,P<0.05。结论:FHIT基因蛋白的失表达和HER2基因蛋白的过表达可能在NSCLC发生和发展过程中起重要作用,并影响预后。

Expressions and clinical significance of FHIT and HER2 proteins in non-small cell lung cancer

OBJECTIVE:To investigate the expressions and clinical significance of FHIT and HER2 proteins in non-small cell lung carcinoma and their correlations.METHODS:The expressions of FHIT and HER2 proteins were detected by SP immunohistochemical technique among pathology specimen(90 cases).RESULTS:The deletion rate of FHIT protein expression in NSCLC tissues 53.75%(43/80)was lower than that in benign pulmonary lesion tissues 10%(1/10)significantly,while the over-expression of HER2 protein in NSCLC tissues 62.50%(50/80)was higher than that in benign pulmonary lesion tissues 0(0/10)significantly,P<0.01.The deletion rate of FHIT protein expression was related to smoking(P=0.000),cancer cell differentiation(P=0.004),lymph node metastasize(P=0.002),pTNM stages(P=0.028)and the rate of cases without recurrence in 3 years(P=0.047)in NSCLC patients.The over-expression of HER2 protein was related to lymph node metastasize or not(P=0.030),pTNM stages(P=0.018)and the rate of cases without recurrence in 3 years(P=0.028)in NSCLC patients.The deletion rate of FHIT protein expression and the over-expression of HER2 protein were negative correlated significantly,P<0.05.CONCLUSION:The deletion rates of FHIT protein expression and the over-expression of HER2 protein may play important roles in the tumorigenesis and the prognosis of NSCLC.