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| Chronic Pulmonary Infection Caused by Mycoplasma Pneumoniae Leading to Pulmonary Arteriole Remodeling and Pulmonary Hypertens | |
| 引用本文： | 刘东旭,彭东信,陈茹,雷汉题,车东媛,赵时宇. Chronic Pulmonary Infection Caused by Mycoplasma Pneumoniae Leading to Pulmonary Arteriole Remodeling and Pulmonary Hypertens[J]. 华中科技大学学报(医学英德文版), 1995, 15(4): 223-226. DOI: 10.1007/BF02887950 |
| 作者姓名： | 刘东旭 彭东信 陈茹 雷汉题 车东媛 赵时宇 |
| 作者单位： | LIU Dong-xu; PENG Dong-xin(Department of Respiratory Disease，Tongji Hospital，Tongji Medical University，Wuhan 430030)CHEN Ru; LEI Han-ti;(Department of Microbiology，Tongji Hospital，Tongji Medical University，Wuhan 430030)CHE Dong-yuan ; ZHAO Shi-yu(Depa |
| 摘 要： | ＣｈｒｏｎｉｃＰｕｌｍｏｎａｒｙＩｎｆｅｃｔｉｏｎＣａｕｓｅｄｂｙＭｙｃｏｐｌａｓｍａＰｎｅｕｍｏｎｉａｅＬｅａｄｉｎｇｔｏＰｕｌｍｏｎａｒｙＡｒｔｅｒｉｏｌｅＲｅｍｏｄｅｌｉｎｇａｎｄＰｕｌｍｏｎａｒｙＨｙｐｅｒｔｅｎｓｉｏｎｉｎＲａｔｓＬＩＵＤｏ... |
| 收稿时间： | 1995-02-06 |
Chronic pulmonary infection caused by mycoplasma pneumoniae leading to pulmonary arteriole remodeling and pulmonary hypertension in rats |
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| Liu Dong-xu PhD,Peng Dong-xin,Chen Ru,Lei Han-ti,Che Dong-yuan,Zhao Shi-yu. Chronic pulmonary infection caused by mycoplasma pneumoniae leading to pulmonary arteriole remodeling and pulmonary hypertension in rats[J]. Journal of Huazhong University of Science and Technology. Medical sciences, 1995, 15(4): 223-226. DOI: 10.1007/BF02887950 | |
| Authors: | Liu Dong-xu PhD Peng Dong-xin Chen Ru Lei Han-ti Che Dong-yuan Zhao Shi-yu |
| Affiliation: | (1) Department of Respiratory Disease, Tongji Hospital, Tongji Medical University, 430030 Wuhan;(2) Department of Microbiology, Tongji Hospital, Tongji Medical University, 430030 Wuhan;(3) Department of Pathology, Tongji Medical University, 430030 Wuhan |
| Abstract: | Summary The pulmonary arteriole remodeling in Wistar rats with respiratory infection induced by mycoplasma pneumoniae was observed using light microscopy and morphometry. The pulmonary artery pressure (PAP) and index of right ventricular hypertrophy (RVHI) were measured. The intimai and medial hypertrophy can be seen in the pulmonary arterioles, leading to vessel wall thickening and narrowing of the lumina. The total number of the pulmonary arterioles decreased (P <0. 01), and both pulmonary hypertension (Ppa 4. 11±0.19 kPa) and right ventricular hypertrophy (RVHI: 34. 96±3. 91 %) occurred. In addition, an interstitial pulmonary fibrosis (IPF) was found, in which the content of collagen in the lung tissue changed, i. e., type I collagen increased whereas type I one decreased, and the ratio of type I collagen to type I one increased. It suggested that respiratory infection induced by repeated MP may result in remodeling of pulmonary arterioles and are closely related to pulmonary hypertension. |
| Keywords: | mycoplasma pneumoniae pulmonary arteriole pulmonary Hypertension |
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