不同危险分层非ST段抬高急性冠脉综合征患者胱抑素-C和超敏C反应蛋白水平分析简

目的 通过检测胱抑素-C（Cys-C）和超敏C反应蛋白（hs-CRP）在不同危险分层的非ST段抬高急性冠脉综合征（NSTEACS）患者的浓度,旨在探讨Cys-C和hs-CRP与不同危险分层的NSTEACS的关系.方法 选取2010年3月～2012年6月鹤山市人民医院住院患者90例,并选取同期住院排除冠心病的患者30例作为正常对照组,其中NSTEACS低危患者30例,中危患者30例,高危患者30例.对90例临床NSTEACS不同危险分层患者和30例正常者依次进行全面的临床特征分析.所有病例于入院即刻、1周抽血测定hs-CRP和Cys-C浓度.结果 hs-CRP入院即刻、1周后水平均随着NSTEACS危险分层级别的增高,其值随之增高.高危组明显高于中、低危组及正常对照组,差异有统计学意义（均P＜ 0.05）.Cys-C入院即刻水平在高危组中最低,与正常对照组相比,差异有统计学意义.1周后高危组水平上升,明显高于正常对照组,差异有统计学意义（均P＜ 0.05）.hs-CRP和Cys-C在入院即刻浓度随着NSTEACS患者危险分层提高,二者呈明显负相关（r=-0.439,P＜0.05）.1周后二者水平值呈正相关（r=0.349,P＜0.05）.结论 联合检测Cys-C和hs-CRP的水平可以判断不同危险分层NSTEACS的严重程度,对NSTEACS的诊治及其预后评价均有重要的参考价值.

Analysis of cystatin-C and high sensitivity C-reactive protein among patients with different risk stratification of non-ST-elevation acute coronary syndrome

Objective To explore the relationship between cystatin-C and high sensitivity C-reactive protein with different risk stratification of non-ST-elevation acute coronary syndrome＇s patients by testing concentrations of Cys-C and hs-CRP in different risk stratification of NSTEACS.Methods 90 patients hospitalized in Heshan People＇s Hospital were chosen,and 30 cases of patients without coronary heart disease hospitalized at the same time were chosen as normal control group,of which,there were 30 cases of low-risk NSTEACS patients,30 cases of moderate-risk NSTEACS patients,30 cases of high-risk NSTEACS patients.The clinical characteristics of 90 patients with different risk stratification of NSTEACS and 30 normal patients were analyzed comprehensively.All patients were tested the hs-CRP and Cys-C concentrations in the immediate admission and one week respectively.Results The concentration of hs-CRP was increased following with NSTEACS risk stratification levels increasing in the immediate admission and one week respectively.There was a significant difference in the high-risk group with low-risk,moderate-risk and normal control group （P 〈 0.05）.The concentration of Cys-C in the immediate admission was the lowest in high-risk group,there was a significant difference in the high-risk group compared with the normal control group （P 〈 0.05）.The concentration of Cys-C was increased after one week,there was also a significant difference in the high-risk group compared with the normal control group （P 〈 0.05）.There was a negative correlation between the concentrations of hs-CRP and Cys-C in the immediate admission with the improving risk stratification in patients with NSTEACS （r =-0.439,P 〈 0.05）.After one week,there was a positive correlation between the concentrations of hs-CRP and Cys-C with the improving risk stratification in patients with NSTEACS （r =0.349,P 〈 0.05）.Conclusion Joint detection of Cys-C and hs-CRP levels can determine different risk stratification NSTEACS severity,which is an important reference value for diagnosis,treatment and prognostic evaluation in the NSTEACS patients.