盐酸戊乙奎醚对腹腔镜下胃癌根治术围术期胃动素和胃泌素的影 响简

目的研究盐酸戊乙奎醚对腹腔镜下胃癌根治术围术期胃泌素（GAS）和胃动素（MTL）的影响。方法选择2010年1月，2012年12月广州中医药大学附属北碚中医院行腹腔镜下胃癌根治术患者200例为研究对象，随机分为麻醉前给予盐酸戊乙奎醚肌内注射的观察组和麻醉前给予常规处理的对照组，每组各100例。观察两组患者进人手术室时（T0）、术中（T1）、手术结束时（T2）、术后1d（T3）、术后2d（T4）时各血液动力学指标及MTL、GAS含量。结果①T0、T1、T2、T3、T4时间点，两组患者收缩压的差异无统计学意义（P〉0．05）；T0、T1时间点，两组患者MTL和GAS含量的差异无统计学意义（P〉0．05）。②T2、T3、T4时间点，观察组患者的GAS含量（78．2±10．5）、（63．8±8．2）、（89．4±12．1）pg／mL]均高于对照组（57．5±7．9）、（41．9±6．7）、（72．3±9．4）pg／mL]，两组相比，差异均有统计学意义（均P〈0．05）；观察组MTL含量（238．3±42．1）、（209．5±33．8）、（274．4±39．6）pg／mL]均高于对照组（158．7±25．2）、（132．4±24．9）、（188．5±23．4）pg／mL）]，两组相比，差异均有统计学意义（均P〈0．05）。结论盐酸戊乙奎醚有助于改善围术期MTL和GAS含量，促进术后胃肠道功能恢复，在腹腔镜下胃癌根治术中具有积极的应用价值。

Effect of penehyclidine hydrochloride on motilin and gastrin in perioper- ative period of patients with gastric cancer undergoing radical correction under laparoscope

Objective To study the effect of Penehyclidine Hydrochloride on motilin （MTL） and gastrin （GAS） in peri- operative period of patients with gastric cancer undergoing radical correction under laparoscope. Methods 200 patients with gastric cancer undergoing radical correction under laparoscope in Beibei Hospital of Traditional Chinese Medicine Affiliated to Guangzhou University of Traditional Chinese Medicine from January 2010 to December 2012 were selected and randomly divided into observation group given Penehyclidine Hydrochloride injection before anesthesia and control group given conventional treatment before anesthesia. Then hemodynamic indexes, levels of MTL motilin and GAS were observed when proceeding into operating room （T0）, in operation （T1）, finishing operation （T2）, 1 day after operation （T3）, 2 days after operation （T4）. Results ①At T0,T1, T2, T3, and T4 time point of perioperation period, there were no signifi- cant difference between two groups of SBP （P 〉 0.05）; at T0, T1, T2 time point of perioperation period, there were no significant difference between two groups of MTL and GAS level （P 〉 0.05）.②At T2, T3, T4 time point, GAS of observa- tion group （78.2±10.5）, （63.8±8.2）, （89.4±12.1） pg/mL] were higher than those of control group （57.5±7.9）, （41.9±6.7）, （72.3±9.4） pg/mL], the differences were statistically significant （P 〈 0.05）; and MTL of observation group （238.3± 42.1 ）, （209.5± 33.8）, （274.4±39.6） pg/mL] were higher than those of control group （158.7±25.2）, （132.4±24.9）, （188.5± 23.4） pg/mL）], content of observation were higher than those of control group, the differences were statistically signifi- cant （P 〈 0.05）. Conclusion penehyclidine hydrochloride lias positive clinical value in laparoscopic gastrectomy for it is helpful to improve motilin and gastrin content in perioperation period and promote the recovery of gastrointestinal func- tion after surgery.