进展期胃癌术前介入治疗疗效的观察

目的观察可手术的进展期胃癌患者根治术前介入治疗的疗效。方法对50例进展期胃癌患者进行术前介入化疗,其中26例合并栓塞治疗,根据癌灶部位进行选择性动脉插管,根据体表面积应用化疗药物,5-Fu750mg/m2,MMC10mg/m2,DDP60mg/m2,介入术后7～14天行外科手术治疗,并行病理学检查,同时观察术后复发率。结果术后50例患者病理学改变总有效率为74.0%。23例出现一过性恶心、呕吐,2例出现黑便,经保守治疗后症状消失。手术后6、12、18、24个月复发率分别为0、2.6%、12.0%、23.6%。结论进展期胃癌术前介入治疗可提高手术切除率,降低术后复发率,并发症少,可作为进展期胃癌术前常规辅助治疗方法。

The Effect of Preoperative Interventionl Therapy for Advanced Gastric Cancer

Objective To evaluate the significance of pre-operative transcatheter arterial chemotherapy（TAC） or gastric arterial embolization（GAE） for advanced gastric cancer（AGC）.Methods 50 cases of AGC underwent TAC/GAE by seldinger techniqe.The anticancer drugs used were 5-Fu 750 mg/m2,MMC 10 mg/m2,DDP 60 mg/m2.All patients were performed operation 7-10 days post TAC/GAE.Histopathological changes were studied in all specimens and the recurrent rates were investigated.Results Twenty-three cases had transient nausea and vomiting.All patients recovered with conservative treatment.Tumor had been resected completely in 50 cases.The overall histopathological response rate was 74.0%.The recurrent rates were 0 at 6 months,2.6% at 12 months,12.0% at 18 months,and 23.6% at 24 months.Conclusion Pre-operative interventional therapy is safe and effective and it is helpful to tumor resected rate and decrease recurrent rate after operation without severe complications.