病毒性脑炎患儿脑脊液NO的测定及其意义

目的 探讨病毒性脑炎患儿脑脊液-氧化氮（NO）含量的变化及其与脑损伤程度的相关性。方法 用比色法检测NO^-2／NO^-3值以反映NO水平，并与20例同期无中枢神经系统器质性病变麻醉手术儿童进行比较；结果 病毒性脑炎患儿急性期脑脊液NO含量较恢复期及对照组明显升高（P均〈0．01）；重症组较轻症组更多（P〈0．01）。结论 病毒性脑炎患儿脑脊液NO含量显著增高，其水平与病情的严重程度相关，脑脊液NO含量的测定可做为病毒性脑炎的辅助检测手段。

The Changes of Nitric Oxide in Cerebrospinal Fluid and its Clinical Significance in Children with viral encephalitis

Objective To investigate the relationship among the changes of nitric oxide in cerebrospinal fluid and severity of injury in children with viral encephalitis. Methods The nitric oxide level of cerebrospinal fluid was determined by colorimetric method in 54 cases with virus encephalitis and 20 normal children undergoing anesthetized operation without organic injury in central nervous system at the same period. Results The nitric oxide levels of cerebrospinal fluid were obviously, higher than those of the control group and those of the cases in convales cent stage (all P<0.01). The cerebrospinal fluid level of No of the serious patient were significantly higher than those of the mild patients(P<0.01). Conclusions Nitric oxide levels of cerebrospinal fluid obviously increased in the children with encephalitis litis mild patients(P<0.01), compared with the healthy children, the increasing degree of nitric oxide relate with the degree of the brain injury. Determination of nitric oxide level of cerebrospinal fluid would help to diagnosis the virus cerebritis.