根除幽门螺杆菌治疗慢性胃炎的疗效观察

目的探讨幽门螺杆菌(Hp)根除治疗在慢性胃炎治疗过程中的临床疗效。方法经胃镜、组织病理学检查和幽门螺杆菌检测确诊为幽门螺杆菌相关性胃炎患者99例分为研究组49例和观察组50例,并以同期53例非幽门螺杆菌相关性胃炎患者作为阴性对照组。研究组给予正规的根除幽门螺杆菌三联治疗,其他各组的基本治疗相同。分析每个组治疗前和治疗后4周、1年～1年6个月随访结束时的症状体征、胃镜检查和组织病理学检查结果。结果治疗结束后4周研究组的炎症严重程度和活动度都比观察组的轻(P<0.05)。研究组的炎症严重程度比治疗前明显好转(P<0.05),观察组则无显著性差异(P>0.05)。研究组的复发率比观察组和阴性对照组的都低(P<0.05)。结论对幽门螺杆菌相关性胃炎患者进行正规的根除幽门螺杆菌治疗可以提高慢性胃炎的临床治疗效果,具有非常重要的临床意义。

Efficacy of eradication of Helicobacter pylori of chronic gastritis

Objective To investigate the clinical efficacy of Helicobacter pylori eradication therapy in the treatment process of chronic gastritis.Methods Totally 99 patients with Helicobacter pylori-associated gastritis diagnosed by the endoscopy,histopathological examination and Helicobacter pylori testing were divided into the study group of 49 patients and the observation group of 50 patients,and during the same period 53 cases of non-helicobacter pylori-associated gastritis as a negative control group.The study group was given a formal eradication of Helicobacter pylori triple therapy,and other groups were given the same basic treatment.Analyze the signs and symptoms,the endoscopy and histopathological examination results of each group before treatment and after 4 weeks,and at the end of 1-1.5 years follow-up.Results The severity and activity of inflammation about the study group were less serious than that of the observation group after 4 weeks behind the end of treatment(P<0.05).The severity of inflammation in the study group was significantly better than that before the treatment(P<0.05),and the observation group were not significantly different(P>0.05).The recurrence rate of study group was lower than those of the observation group and the negative control group.Conclusion Regular treatment of Helicobacter pylori eradication in patients of Helicobacter pylori-associated gastritis can improve the clinical treatment of chronic gastritis,which has a very important clinical significance.