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| 米托坦的合成 | |
| 引用本文： | 邓莉平,陶伟锋,王玮,张泳,吴春雷. 米托坦的合成[J]. 中国医药工业杂志, 2012, 43(3): 170-171 |
| 作者姓名： | 邓莉平 陶伟锋 王玮 张泳 吴春雷 |
| 作者单位： | 绍兴文理学院药学系,浙江绍兴,312000 |
| 摘 要： | 2-氯苯甲醛和氯仿在氢氧化钾甲醇溶液和DMF中反应得到2,2,2-三氯-1-(2-氯苯基)乙醇,再经铝汞齐还原、与氯苯在浓硫酸作用下反应制得抗肿瘤药米托坦,总收率约27%。 |
| 关 键 词： | 米托坦 抗肿瘤药 合成 |
Synthesis of Mitotane |
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| DENG Liping , TAO Weifeng , WANG Wei , ZHANG Yong , WU Chunlei. Synthesis of Mitotane[J]. , 2012, 43(3): 170-171 | |
| Authors: | DENG Liping TAO Weifeng WANG Wei ZHANG Yong WU Chunlei |
| Affiliation: | (Dept.of Pharmacy,Shaoxing University,Shaoxing 312000) |
| Abstract: | Mitotane,an antineoplastic agent,was synthesized from 2-chlorobenzaldehyde by reaction with chloroform in KOH/CH3OH and DMF to give 2,2,2-trichloro-1-(2-chlorophenyl)ethanol,which was subjected to reduction followed by reaction with chlorobenzene in the present of sulfuric acid with an overall yield of about 27%. |
| Keywords: | mitotane antineoplastic agent synthesis |
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