间苯三酚应用于产程不同时期的效果分析

目的:探讨间苯三酚应用于产程不同时期的促进作用。方法:150例正常足月妊娠初产妇随机分为3组,孕妇潜伏期使用间苯三酚组(A组)、潜伏期及活跃期联合使用间苯三酚组(B组)和对照组(C组)。当孕妇规律宫缩进入潜伏期时,A、B两组均予间苯三酚80 mg静脉注射,对照组则不予药物处理;宫口开大3 cm时,B组给予间苯三酚40 mg宫颈注射。记录3组产妇的宫口扩张速度和时间(第一产程潜伏期、活跃期时间,第二产程时间)、宫颈水肿发生率、疼痛程度、宫缩及胎心情况、剖宫产率、产时羊水情况、新生儿Apgar评分、产后2小时出血量以及用药过程中母儿不良反应。结果:A、B两组子宫颈口从用药至开全的时间明显短于对照组(P<0.01),其子宫颈口的扩张速度也明显快于对照组(P<0.01)、阴道分娩率明显高于对照组(P<0.05),其中B组活跃期时间明显短于A组;而3组间的新生儿Apgar评分、产后2 h出血量相近(P>0.05)。观察组产妇用药后母儿未出现明显不良反应。结论:产妇在潜伏期静脉注射间苯三酚可加速宫口扩张,对缩短潜伏期有一定的临床意义;潜伏期及活跃期联合使用间苯三酚效果更佳。间苯三酚能加速产妇子宫颈口扩张、缩短产程、提高阴道分娩率,且对母儿无明显不良影响。

Analysis on the effect of application of phloroglucin during different stages of labor

Objective:To explore the promoting effect of phloroglucin used during different stages of labor.Methods:A total of 150 normal full-term primiparous women were randomly divided into three groups: group A(the women were treated with phloroglucin during latent period),group B(the women were treated with phloroglucin during latent period and active period),and group C(control group).When regular uterine contraction appeared and the women entered into latent period,the women in group A and group B were treated with intravenous injection of phloroglucin(80 mg),while the women in group C were not treated with any drug;when the diameter of uterine mouth was 3 cm,the women in group B were treated with cervical injection of phloroglucin(40 mg).The speeds and duration times of cervical dilatation(the duration time of latent period during the first stage of labor,the duration time of active period during the first stage of labor,the duration time of the second stage of labor),the incidences of cervical edema,the degrees of pain,the degrees of uterine contraction,fetal heart rates,the rates of cesarean section,the volumes of amniotic fluid in labor,neonatal Apgar scores,the amounts of postpartum hemorrhage at two hours,maternal and fetal adverse reactions in the three groups were recorded.Results:The times from drug use to full dilatation of cervix in group A and group B were statistically significantly shorter than that in group C(P<0.01),the speeds of cervical dilatation in group A and group B were statistically significantly quicker than that in group C(P<0.01),the rates of vaginal delivery in group A and group B were statistically significantly higher than that in group C(P<0.05).The duration time of active period in group B was statistically significantly shorter than that in group A;there was no statistically significant difference in neonatal Apgar score and the amount of postpartum hemorrhage at two hours among the three groups(P>0.05).No apparent adverse reactions occurred in group A and group B after treatment.Conclusion:Injecting phloroglucin during latent period for primiparous women can fasten cervical dilatation and have a certain clinical significance for shortening latent period;combined application of phloroglucin during latent period and active period can achieve better effect;phloroglucin can fasten cervical dilatation,shorten stages of labor,and improve the rate of vaginal delivery,which has no apparent adverse impact on the mothers and fetuses.