1000例肾活检儿童临床与病理分析

目的探讨肾活检儿童的临床、病理特点及两者之间的关系。方法回顾性分析1 000例肾脏病患儿临床与肾脏病理资料。结果 1 000例患儿肾活检取材成功962例,成功率96.2%。患儿术后出现轻度并发症170例,并发症发生率为17%。临床表现与病理大部分符合,但有20例临床与病理诊断不符。结论儿童肾脏病的临床表现轻重与病理改变轻重并不平行,仅凭临床表现进行诊治,有误诊、过度治疗、延误治疗的可能,病理诊断对临床治疗及预后评价具有重要的指导意义。

The clinical and pathological analysis of 1 000 cases with renal biopsies in children

Objective To explore the clinical and pathological features,and the correlation between clinical and pathological diagnoses in 1 000 children with renal biopsies.Methods In 1 000 children with renal diseases,the renal biopsies were performed using semi automatic biopsy needles under ultrasound guidance.The clinical and renal pathological data were analyzed retrospectively.Results In 96.2%(n = 962)of cases,renal biopsies were obtained successfully.Mild complications occurred in 17% patients(n = 170).Most of clinical manifestations were consistent to pathological diagnosis,but 20 cases were not.Conclusions There was considerable proportion of patients who were misdiagnosed and had excessive treatment or delayed treatment for pediatric renal diseases if diagnosed only by clinical manifestation.The pathological diagnosis provides guidances and significantly improves clinical treatment and prognostic assessment.