The effect of childbirth on carcinogenesis of DMBA-induced breast cancer in female SD rats |
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| Authors: | Zhao Ji-An Chen Jin-Jun Ju Ying-Chao Wu Jian-Hua Geng Cui-Zhi Yang Hui-Chai |
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| Affiliation: | Ji-An Zhao1,Jin-Jun Chen1,Ying-Chao Ju2,Jian-Hua Wu2,Cui-Zhi Geng3 and Hui-Chai Yang41Department of Hepatobiliary Surgery,The First Affiliated Hospital,Hebei Medical University,Shijiazhuang,Hebei 050013,P. R. China,2Experimental Animal Center,3Department of Breast Clinics Center,4Department of Pathology,The Fourth Affiliated Hospital,Hebei 050011,P. R. China. |
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| Abstract: | ![]()
Many epidemiologic and clinical studies have indicated that the frequency of breast cancer was lower in parous women than in nulliparous women. Moreover, the incidence of breast cancer has been reported to be lower in women with early childbirth than in women with late childbirth. To verify the effect of childbirth and the age at first childbirth on carcinogenesis and progression of breast cancer, we induced breast cancer by 7,12-dimethylbenanthracene (DMBA) in 120 female Sprague-Dawley (SD) rats, and divid... |
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| Keywords: | 7 12-Dimethylbenanthracene (DMBA) childbirth nulliparity breast cancer rat |
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