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| 初治与复发性卵巢上皮癌组织中BRCA1、ERCC1、TUBB3、PRR13基因mRNA表达变化 | |
| 引用本文： | 赵丹,王小兵,常青云,田海梅,李茉,宋培培,刘静,齐军,张伟.初治与复发性卵巢上皮癌组织中BRCA1、ERCC1、TUBB3、PRR13基因mRNA表达变化[J].癌症进展,2011,0(5):573-576. |
| 作者姓名： | 赵丹 王小兵 常青云 田海梅 李茉 宋培培 刘静 齐军 张伟 |
| 作者单位： | 1. 中国医学科学院北京协和医学院肿瘤医院妇瘤科,北京,100021 2. 中国医学科学院北京协和医学院肿瘤医院生物检测中心,北京,100021 3. 中国医学科学院北京协和医学院肿瘤医院检验科,北京,100021 |
| 摘 要： | 目的 比较BRCA1、ERCC1、TUBB3、PRR13基因mRNA表达在初治和复发性卵巢上皮癌组织中的表达水平的差异,初步探讨该4种耐药相关基因与卵巢癌获得性耐药的关系.方法采用荧光定量PCR方法检测46例原发性卵巢上皮癌和14例复发性卵巢上皮癌组织标本中BRCA1、ERCC1、TUBB3、PRR13基因mRNA表... |
| 关 键 词： | 复发性卵巢癌 获得性耐药 |
Comparison of BRCA1,ERCC1,TUBB3,PRR13 gene mRNA expression in primary and recurrent epithelial ovarian cancer |
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| Zhao Dan Wang Xiaobing Chang Qingyun Tian Haimei Li Mo Song Peipei Liu Jing Qi Jun Zhang Wei Gynecologic Oncology,Detection Center of Tumor Biology,Clinical Laboratory,Cancer Institute & Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing ,China.Comparison of BRCA1,ERCC1,TUBB3,PRR13 gene mRNA expression in primary and recurrent epithelial ovarian cancer[J].Oncology Progress,2011,0(5):573-576. | |
| Authors: | Zhao Dan Wang Xiaobing Chang Qingyun Tian Haimei Li Mo Song Peipei Liu Jing Qi Jun Zhang Wei Gynecologic Oncology Detection Center of Tumor Biology Clinical Laboratory Cancer Institute & Hospital Chinese Academy of Medical Sciences & Peking Union Medical College Beijing China |
| Institution: | Zhao Dan1 Wang Xiaobing2 Chang Qingyun2 Tian Haimei2 Li Mo2 Song Peipei2 Liu Jing2 Qi Jun3 Zhang Wei2 1Gynecologic Oncology,2Detection Center of Tumor Biology,3Clinical Laboratory,Cancer Institute & Hospital,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100021,China |
| Abstract: | Objective To evaluate BRCA1,ERCC1,TUBB3 and PRR13 mRNA expression levels in primary and recurrent epithelial ovarian cancer tissues and to explore the relationship between these drug resistance genes and acquired drug resistance of ovarian cancer.Methods Totally 46 primary epithelial ovarian and 14 recurrent epithelial ovarian tumor samples were collected from the patients who received cytoreductive surgery.Real-time quantitative PCR was used to analyze the mRNA expression of BRCA1,ERCC1,TUBB3 and PRR13 in ... |
| Keywords: | recurrent ovarian cancer acquired drug resistance |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |