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Molecular targets for the protodynamic action of cis-urocanic acid in human bladder carcinoma cells |
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| Authors: | Emilia Peuhu Aura Kaunisto Jarmo K Laihia Lasse Leino John E Eriksson |
| Affiliation: | 1.Turku Centre for Biotechnology,University of Turku and ?bo Akademi University, BioCity,Turku,Finland;2.Department of Biosciences,?bo Akademi University,Turku,Finland;3.BioCis Pharma Ltd.,Turku,Finland |
| Abstract: | Backgroundcis-urocanic acid (cis-UCA) is an endogenous amino acid metabolite capable of transporting protons from the mildly acidic extracellular medium into the cell cytosol. The resulting intracellular acidification suppresses many cellular activities. The current study was aimed at characterizing the molecular mechanisms underlying cis-UCA-mediated cytotoxicity in cultured cancer cells. |
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