Characterization of bortezomib-adapted I-45 mesothelioma cells |
| |
| Authors: | Lidong Zhang James E Littlejohn Yu Cui Xiaobo Cao Chander Peddaboina W Roy Smythe |
| |
| Institution: | (1) Section of Surgery Research, Department of Surgery, Texas A & M University Health Science Center College of Medicine and Scott & White Memorial Hospital, Temple, Texas, USA;(2) Department of Oncology, Tianjin Union Medicine Center, Tianjin, China |
| |
| Abstract: | Background Bortezomib, a proteasome-specific inhibitor, has emerged as a promising cancer therapeutic agent. However, development of
resistance to bortezomib may pose a challenge to effective anticancer therapy. Therefore, characterization of cellular mechanisms
involved in bortezomib resistance and development of effective strategies to overcome this resistance represent important
steps in the advancement of bortezomib-mediated cancer therapy. |
| |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ |
|
