Prospective screening study of 0.5 Tesla dedicated magnetic resonance imaging for the detection of breast cancer in young, high-risk women |
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Authors: | Wendy S Rubinstein Jean J Latimer Jules H Sumkin Michelle Huerbin Stephen G Grant Victor G Vogel |
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Affiliation: | (1) Department of Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL, USA;(2) Evanston Northwestern Healthcare Center for Medical Genetics, Evanston, IL, USA;(3) Department of Obstetrics, Gynecology and Reproductive Sciences, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA;(4) Research Institute, Magee-Womens Hospital, Pittsburgh, PA, USA;(5) University of Pittsburgh Cancer Institute, Pittsburgh, PA, USA;(6) Department of Radiology, Magee-Womens Hospital, Pittsburgh, PA, USA;(7) Department of Environmental and Occupational Health, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA, USA;(8) Department of Medicine, School of Medicine, University of Pittsburgh, Pittsburgh, PA, USA |
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Abstract: |
Background Evidence-based screening guidelines are needed for women under 40 with a family history of breast cancer, a BRCA1 or BRCA2 mutation, or other risk factors. An accurate assessment of breast cancer risk is required to balance the benefits and risks of surveillance, yet published studies have used narrow risk assessment schemata for enrollment. Breast density limits the sensitivity of film-screen mammography but is not thought to pose a limitation to MRI, however the utility of MRI surveillance has not been specifically examined before in women with dense breasts. Also, all MRI surveillance studies yet reported have used high strength magnets that may not be practical for dedicated imaging in many breast centers. Medium strength 0.5 Tesla MRI may provide an alternative economic option for surveillance. |
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