艾司西酞普兰合并奥氮平治疗抑郁症的疗效观察

目的观察艾司西酞普兰合并奥氮平治疗抑郁症的临床疗效和安全性。方法将80例抑郁症患者随机分为观察组和对照组各40例,观察组给予艾司西酞普兰合并奥氮平治疗,对照组仅用艾司西酞普兰治疗,疗程为12周。治疗结束后采用汉密尔顿抑郁量表(HAMD)、不良反应应量表(TESS)分别评定临床疗效及不良反应。结果两组HAMD评分较治疗前均显著性降低(P<0.05)。治疗后第8、12周末,研究组的HAMD评分显著低于对照组(P<0.05)。两组均未发生严重不良反应,不良反应率差异无显著性(P>0.05)。结论艾司西酞普兰合并奥氮平治疗抑郁症疗效显著,安全可靠,值得临床推广应用。

The Effect Observation of Escitalopram Combined with Olanzapine in the Treatment of Depression Disorder

Objective To observe the clinical effects and safety of using escitalopram combined with olanzapine in the treatment of depression disorder.Methods 80 cases of patients with depression disorder as studied object,and randomly divided them into observation group and control group,40 cases in each group.Control group was treated with escitalopram for 12 weeks;while observation group was treated with escitalopram combined with olanzapine for 12 weeks.The efficacy and side effects were evaluated with Hamilton Depression Rating Scale（HAMD） and Treatment Emergent Symptom Scale（TESS） after the treatment.Results Scores of HAMD in two groups both decreased significantly（P0.05） after the treatment.Scores of HAMD in observation group were significantly lower than that in control group at the 8th and 12th weekend（P0.05）.There is no serious side-effect that happened in two groups,and the side-effect rates in two groups have no significant difference（P0.05）.Conclusion Escitalopram combined with olanzapine has better effect than escitalopram monotherapy in the treatment of depression disorder with satisfactory tolerability.SO it deserves to apply and prompt it on clinical work.