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| Z24系列化合物遗传毒性的优化筛选 | |
| 引用本文： | 秦爱平,袁素波,马华智,吴纯启,廖明阳. Z24系列化合物遗传毒性的优化筛选[J]. 中国新药杂志, 2006, 15(10): 773-776 |
| 作者姓名： | 秦爱平 袁素波 马华智 吴纯启 廖明阳 |
| 作者单位： | 军事医学科学院毒物药物研究所,北京,100850 |
| 摘 要： | 目的：对Z24系列化合物进行遗传毒性优化筛选,从中选出毒性较低的候选新药作进一步开发.方法：采用Ames波动试验,SOS显色试验和双核细胞微核试验比较5种Z24系列化合物（Z24,SU5416,L1,L3和L4）的遗传毒性.结果：Ames波动试验结果表明除Z24外,其他4种化合物均显示致突变性;SOS显色试验则表明5种化合物均无致DNA原发损伤作用;双核细胞微核试验显示SU5416,L1,L3和L4具有致染色体断裂效应.结论：Z24是该系列化合物中最具开发前景的候选新药. |
| 关 键 词： | Z24系列化合物 遗传毒性 优化筛选 |
| 文章编号： | 1003-3734（2006）10-0773-04 |
| 修稿时间： | 2005-10-25 |
Optimization of Z24 serial chemicals with less genetic toxicity in vitro |
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| QIN Ai-ping,YUAN Su-bo,MA Hua-zhi,WU Chun-qi,LIAO Ming-yang. Optimization of Z24 serial chemicals with less genetic toxicity in vitro[J]. Chinese Journal of New Drugs, 2006, 15(10): 773-776 | |
| Authors: | QIN Ai-ping YUAN Su-bo MA Hua-zhi WU Chun-qi LIAO Ming-yang |
| Affiliation: | Institute of Pharmacology and Toxicology, Academy of Military Medical Science, Beijing 100850, China |
| Abstract: | Objective:To make Z24 serial chemicals with less genetic toxicity optimized in vitro for further drug development.Methods:The genetic toxicities of five Z24 serial chemicals (Z24, SU5416,L1,L3 and L4)were evaluated by the Ames-fluctuation test,SOS chromotest and the cytokine- sis-block micronucleus assay.Results:All compounds but Z24 showed mutagenic effects in the Ames- fluctuation test on strain TA100,and had chromatic fragmentation effects in the binucleated micronucleus assay.No essential damnification to DNA by the five chemicals was found in the SOS chromotest.Con- clusion:Z24 with less genetic toxicity is warranted for further development. |
| Keywords: | Z24 serial chemicals genotoxicity optimal screening |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |