玛咖提取物对大鼠耐力和血抗氧化酶活性的影响

目的 探讨玛咖提取物对大鼠耐力和血抗氧化酶活性的影响。方法 采用循环水流自由游泳和/或给予大鼠8.0、16.0、32.0 g.kg_-1体重玛咖提取物,连续给药15 d,第16天测定耐力和血丙二醛(malondialdehyde,MDA)、 超氧化物歧化酶(superoxide dismutase ,SOD)、谷胱甘肽过氧化物酶(glutathione peroxidase,GSH-px)水平。结果 给予玛咖提取物8.0、16.0、32.0 g.kg_-1体重15 d,沉下前游泳时间和游泳总时间分别延长了34.38%、84.25%、126.07%和37.42%、47.03、107.24%( P<0.01),大鼠沉下次数比单纯游泳组分别减少了17.65%、33.28%、55.50%( P<0.01), MDA水平分别降低了34.63%、54.13%、63.73％(P<0.01),SOD和GSH-px水平分别升高了67.78%,108.25%、154.49％和48.57%、110.28%、154.86%(P<0.01)。结论 玛咖提取物具有抵抗疲劳,增强运动能力的作用。其机制与降低血MDA水平,提高血SOD和GSH-px活性作用有关。

Effect of the Maca Extract on Endurance and Blood Antioxidant Enzyme Activity of Rats

OBJECTIVE To study the Maca extract on endurance of rats and the effect of blood antioxidant enzyme activity. METHODS The Wistar rats treated with/without the Maca extract (8.0, 16.0, 32.0 g·kg^-1) were freely swimming in the circulating water flow daily for 15 d. On the 16th day of experiment, the blood was collected. The endurance, blood malondialdehyde(MDA), superoxide dismutase(SOD), glutathione peroxidase(GSH-Px) level were determinated.RESULTS Compared with those swimming rats without extract treatment, when rats were administered with Maca extract at the doses of 8.0, 16.0, 32.0 g·kg^-1, the swimming time before sinking and the total swimming time were increased by 34.38%, 84.25%, 126.07%(P<0.01) and 37.42%, 47.03%, 107.24%(P<0.01), respectively. The times of sinking was decreased by 17.65%, 33.28%, 55.50%(P<0.01 or P<0.05), respectively. The MDA content in the blood of the rats treated with 8.0, 16.0, 32.0 g·kg^-1 was reduced by 34.63%, 54.13% , 63.73% respectively(P<0.01), while the levels of SOD and GSH-Px were enhanced by 67.78%, 108.25%, 154.49%(P<0.01) and 48.57%, 110.28%, 154.86%(P<0.01), over those of rats without treatment, respectively. CONCLUSION The maca extract has resist fatigue, enhance exercise capacity effect. The mechanism is associated with reduced blood MDA, improve the activity of SOD and GSH-Px.