| 血管生成素-2和血管内皮生长因子在急性白血病中的表达及意义 |
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| 引用本文： | 王萍,阮林海,赵小强.血管生成素-2和血管内皮生长因子在急性白血病中的表达及意义[J].中国实验血液学杂志,2010,18(1):11-14. |
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| 作者姓名： | 王萍 阮林海 赵小强 |
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| 作者单位： | 河南科技大学第一附属医院血液科,河南洛阳,471003 |
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| 摘 要： | 本研究探讨血管血管生成素-2(Ang-2)和内皮生长因子(VEGF)的表达及其与急性白血病(AL)血管新生的关系。应用酶联免疫吸附试验(ELISA)测定24例AL初发未治,18例完全缓解(CR),7例未缓解,13例复发患者血清中Ang-2和VEGF的含量,并与正常对照组比较。结果表明:AL初发未治组、未缓解组、复发组患者血清Ang-2和VEGF的含量均明显高于正常对照组(p0.01);CR组患者血清Ang-2和VEGF的含量较初发未治组明显下降,但与正常对照组比较,其差异都无统计学意义(p0.05);未缓解组和复发组血清Ang-2、VEGF的含量均明显高于CR组(p0.01)。结论:Ang-2和VEGF与AL的发生、发展密切相关,VEGF可能通过上调Ang-2促进AL的血管新生及发展,阻抗Ang-2和VEGF有望成为白血病治疗新的靶点。
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| 关 键 词： | 急性白血病 血管内皮生长因子 血管生成素-2 |
Expression of Angiogenin-2 and VEGF in Acute Leukemia and Its Significance |
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| WANG Ping,RUAN Lin-Hai,ZHAO Xiao-Qiang.Expression of Angiogenin-2 and VEGF in Acute Leukemia and Its Significance[J].Journal of Experimental Hematology,2010,18(1):11-14. |
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| Authors: | WANG Ping RUAN Lin-Hai ZHAO Xiao-Qiang |
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| Institution: | (Department of Hematology, The First Affiliated Hospital, Henan University of Science and Technology, Luoyang 471003, Henan Province, China) |
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| Abstract: | The aim of study was to investigate the expression of angiogenin-2(Ang-2) and vascular endothelial growth factor(VEGF) expression in acute leukemia(AL) and its significance in the angiogenesis and progress of AL.Serum levels of Ang-2 and VEGF in 24 de novo,18 complete remitted(CR),7 unremitted,13 relapsed patients with AL were measured by enzyme-linked immunosorbent assay(ELISA),and compared with those of normal controls.The results showed that the serum levels of Ang-2 and VEGF in de novo,unremitted and re... |
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| Keywords: | acute leukemia VEGF Angiogenin-2 |
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