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| 白藜芦醇对人肝癌细胞系HepG2抑制作用的探讨 | |
| 引用本文： | 费洪新,欧芹,黄小义,魏晓东,张涛,张鹏霞,江旭东. 白藜芦醇对人肝癌细胞系HepG2抑制作用的探讨[J]. 黑龙江医药科学, 2006, 29(4): 30-31 |
| 作者姓名： | 费洪新 欧芹 黄小义 魏晓东 张涛 张鹏霞 江旭东 |
| 作者单位： | 佳木斯大学生物化学教研室,黑龙江,佳木斯,154007;哈尔滨医科大学遗传学教研室,黑龙江,哈尔滨,150086 |
| 摘 要： | 目的:观察白藜芦醇(Res)对体外培养的人肝癌细胞系HepG2生长增殖的影响.方法:采用MTT法、流式细胞仪分析Res对肝癌细胞系HepG2细胞生长的影响及其细胞周期的变化,并且检测端粒酶的活性.结果:Res对肝癌细胞系HepG2的增殖具有抑制作用,IC50为5.91mg/L,流式细胞仪显示,Res能引起肝癌细胞系HepG2细胞的S期阻滞,Res也能显著地抑制端粒酶的活性.结论:Res通过改变肝癌细胞系HepG2细胞的细胞周期分布来抑制人肝癌细胞系HepG2细胞的生长. |
| 关 键 词： | 白藜芦醇 肿瘤细胞 抑制 |
| 文章编号： | 1008-0104(2006)04-0030-02 |
| 修稿时间： | 2006-03-20 |
Depressant effect of resveratrol on human hepatoma cell line HepG2 cells |
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| FEI Hong-xin,OU Qin,HUANG Xiao-yi,WEI Xiao-dong,ZHANG Tao,ZHANG Peng-xia,JIANG Xu-dong. Depressant effect of resveratrol on human hepatoma cell line HepG2 cells[J]. Heilongjiang Medicine and Pharmacy, 2006, 29(4): 30-31 | |
| Authors: | FEI Hong-xin OU Qin HUANG Xiao-yi WEI Xiao-dong ZHANG Tao ZHANG Peng-xia JIANG Xu-dong |
| Abstract: | Objective: To measure the effect of resveratrol on the hepatoma cell line HepG2 cells cultured in vitro.Methods: We used MTT assay and flow cytometry to examine the effect of resveratrol on the hepatoma cell line HepG2 cell growth and the change of cell cycle of HepG2 cells,and detected telomerase activities.Results: Resveratrol had inhibitory action on the proliferation of hepatoma cell line HepG2,with IC_(50) of 5.91mg/L,flow cytometry analysis revealed that resveratrol could induce the S phase arrest of hepatoma cell line HepG2 and had an obvious depressant effect on telomerase activities.Conclusion: Resveratrol has obvious anti-tumor activities on murine hepatoma HepG2 by inducing S phase arrest. |
| Keywords: | resveratrol tumor cells inhibition |
| 本文献已被 CNKI 维普 万方数据 等数据库收录！ | |