甲状腺球蛋白及抗体在结节性甲状腺肿和甲状腺癌的鉴别诊断价值

目的回顾性分析患者术前甲状腺球蛋白（TG）及甲状腺球蛋白抗体（TGAb）的水平，探讨其在结节性甲状腺肿和甲状腺癌的鉴别诊断意义。方法选取2006年1月至2007年1月承德市中心医院普外科180例分化型甲状腺癌（differentiated thyroid carcinoma，DTC）为A组，150例结节性甲状腺肿为B组，健康人120例为对照组（C组）。所有入选对象均行甲状腺超声、甲状腺功能及甲状腺CT检查。结果A组TG和TGAb分别为40．0％和43．3％显著高于B组7．33％和9．33％及C组4．17％和7．50％，A组与B、C组之间差异有统计学意义（P〈0．05），但B组与C组差异无统计学意义（P〉0．05）。结论TG及TGAb测定在结节性甲状腺肿和甲状腺癌的鉴别诊断上有临床意义。

Thyroglobulin and thyroglobulin antibody in differential diagnosis between differentiated thyroid carcinoma and nodular goiter

Objective To investigate the clinical significance of thyroglobulin（TG） and thyroglobulin antibody （TGAb）in differential diagnosis between nodular goiter and differentiated thyroid carcinoma（ DTC ）. Meth- ods From Jan. 2006 to Jan. 2007, 180 cases of thyroid carcinoma were included in group A（male：45, average age ：47 ; female ： 135, average age ： 43） and 150 cases of nodular goiter were included in group B（ Male ：55, average age 43; female：95, average age：41 ）. All the cases came from the General Department of Chengde Central Hospital. Group C （ the control group） included 120 cases （ male ： 40, average age ： 38 ; female ： 80, average age ： 44 ）. All patients underwent thyroids ultrasound, thyroid function detection and CT. Results The positive rate of TG and TGAb was 40. 0% and 43.3% in group A, which were obviously higher than those in group B （7. 33%, 9. 33% ）and group C （4. 17%, 7. 50% ）. The difference had statistical significance （P 〈 0. 05 ）. However, there was no statistical difference between group B and group C （P 〉 0. 05）. Conclusion The measurement of TG and TGAb has clinical significance in differential diagnosis between DTC and nodular goiter.