淀粉样蛋白Aβ1—42在阿尔茨海默病中的意义

目的：探讨老年人阿尔茨海默病（Alzheimer‘s disease,AD)脑脊液淀粉样蛋白Aβ1－42的含量及其意义。方法：采用ELISA法检测30例AD，非AD痴呆患者25例和对照组21例患者脑脊液中Aβ1－42的浓度。结果：AD患者脑脊液中Aβ1－42水平明显低于非AD痴呆和对照组。结论：Aβ1－42在AD的发病中起重要作用，脑脊液Aβ1－42值对AD的诊断具有一定的临床应用价值。

Cerebrospinal fluid levels of beta-amyloid protein 1-42 in Alzhemier disease]

OBJECTIVE: To study the role of beta-amyloid protein 1-42 (A beta 1-42) content in the cerebrospinal fluid (CSF) of Alzheimer disease (AD) patients. METHODS: A beta 1-42 levels were measured with the ELISA method in AD (n = 30), non-AD (NAD, n = 25) and non-dementia (ND, n = 21). RESULTS: The A beta 1-42 mean value for AD was (109.91 +/- 58.78) fmol.L-1. In ND, the A beta 1-42 mean value was (242.40 +/- 142.58) fmol.L-1. The mean value for AD was significantly lower than that of ND. In NAD, the A beta 1-42 mean value was (231.70 +/- 143.94) fmol.L-1, and it was not significantly different from the mean value for ND. The A beta 1-42 level was positively correlated with the severity of AD symptoms, but not with the duration. A beta 1-42 levels in CSF of AD were significantly lower than that of ND, and they decreased as the severity of disease increased. CONCLUSION: Cerebrospinal fluid beta-amyloid 1-42 analyses may be of value in the clinical diagnosis of Alzheimer's disease, especially in the earlier course of the disease, when drug therapy may have the greatest effect but clinical diagnosis is particularly difficult.