多孔钽的理化/生物特性及其骨整合能力研究进展

近年来,以钛合金为主的骨骼材料得到了广泛的应用。临床研究中,植入体的腐蚀磨损和骨整合能力不足是造成其无菌性松动的主要原因,最终可导致手术失败。因此制备综合性能优越的植入体材料是骨组织工程研究的热点。多孔钽拥有良好的理化性质,耐腐蚀和抗磨损性能出色,其良好的生物相容性和多孔结构可以促进新骨的长入和成骨细胞的增殖,从而提高骨整合能力。并且表面改性技术的发展赋予了多孔钽更加优良的性能和功能,扩展了其临床应用。本文将针对多孔钽的理化/生物特性及其骨整合能力的研究进展进行综述。

Researchprogress on the physico-chemical/biological characteristics and osseointegration of porous tantalum

In recent years, the bone materials based on titanium and its alloys have been widely used. In clinical research, the corrosion and wearof implants and the lack of osseointegrationare the two main causes for the aseptic loosening, which can eventually lead to the failure of implantation. So, it is a hotspot in the area of bone tissue engineering to prepare the high performance material. Porous tantalum has satisfactoryphysico-chemical properties and can resist the corrosion and wear, meanwhile, its biocompatibility andporous structure can significantly promotethe ingrowth of new bone and the proliferation of osteoblast, further improve the capacity ofosseointegration. The development of surface modification technology givesporous tantalum more excellent performance and function, and expands its clinical application.In this paper, the physico-chemical/biological characteristics and osseointegration of porous tantalum will be reviewed.